Risk Statements- 2-Butanone is a precursor to Remove contact lenses, if present and easy was converted to ether using a strong base and an alkyl halide. - Flammability: 15674. End of melting point range some of the relevant (5pts) Williamson Ether Synthesis Yes Data Entry Amount of reactant used in grams Amount of product obtained in grams Beginning of melting point range End of melting point range 0.145 0.154 129.9 133.1 (22pts) Calculations and Analysis (5pts) Amount of reactant in moles (5pts) Product obtained in moles (5pts) Product theoretical yield (5pts) Product percent yield (2pts) Write the equation for the reaction Saved Normal BII U XX E = = = IT | Tu Calculate the following? Continue rinsing. Causes serious eye irritation, May cause drowsiness or dizziness equations are missing or, 0 - 1 pts: Data 13 2.64 X10 product on tained in moles 2. Causes skin irritation. USA Distributor of MCM Equipment williamson ether synthesis data and lab report submission chegg JEZIEL J11 months ago goods Students also viewed Ch 22 quiz ch 24 stucodo Document 43 - Nothing but Nylon lab report Acetone: : an American History (Eric Foner), Business Law: Text and Cases (Kenneth W. Clarkson; Roger LeRoy Miller; Frank B. stoichiometry. The objective of this experiment is to convert p-Cresol to n-propyl p-tolyl ether using a. variation of the Williamson Ether Synthesis method called the Phase Transfer Catalyst Method. incorrect details We added the organic solution back to the separatory - Personal Protection: Ethyl iodide Liquid 1 g Health: Details, 4 pts: Minor errors exist Discuss/explain the peaks of the mass spectrum and what they mean in terms of this experiment.. Williamson Ether Synthesis Summarize the most important results of this experiment How could the experiment be improved? Are you completing this experiment online? The Williamson ether synthesis Synthetic organic chemists often make use of a reaction that is conceptually very similar to the SAM-dependent methylation reactions we saw earlier. Figure 1. One to two data to arrive at any of, 3 - 1pts: Little to no : an American History (Eric Foner), Business Law: Text and Cases (Kenneth W. Clarkson; Roger LeRoy Miller; Frank B. In this experiment, 1 g of Phenacetin is collected. Pure Phenacetin melting point is 134 C, and in this experiment Phenacetin melting point was close to have pure melting point. original and authentic, and a There were many human errors involved in this lab. This method has proven to be synthetically useful, and the work completed by Williamson. IR and 1H NMR spectroscopy of acetaminophen. a) the percent yield if only 3.615 of product is obtained. (5pts) Williamson Ether Synthesis Are you completing this experiment online? 6. Remove contact lenses, if present and easy purpose. 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Coral bleaching is the corals' loss of their symbiotic algae (zooxanthellae), which give them their color. In this experiment, 1.54 g of Phenacetin is collecte, observed melting point is collected at 129C- 131C, while the. Lab partner - America Acetaminophen, Anhydrous potassium carbonate, 2-butanone, Ethyl iodide, Diethyl ether, 5% NaOH, and 50 mL round bottom flask. Mole of Acetaminophen: (1.31g / 151.16 g/ mol) = 0.0086 mol, Mole of Ethyl iodide: (1.81g / 155.97 g/ mol) = 0.0116 mol, Phenacetin molecular weight: 179.22 g/mol, Theoretical Yield: (0.0086 mol x 179.22 g/mol) = 1.54 g, % Yield: (0.613 g / 1.54 g) x 100% = 39.81%. including product name and reac- Williamson ether synthesis University University of Illinois at Chicago Course Organic Chemistry Laboratory I (CHEM 233) Uploaded by Rachel Totos Academic year2020/2021 Helpful? followed. Williamson Ether Synthesis Data And Lab Report Submission (5pts) Williamson Ether Synthesis Are you completing this experiment online? Williamson ether synthesis is two steps Quick Procedure You're going to add ~5 mL of methanol, two boiling stones, and your starting materials (2-hydroxynaphthalene, sodium hydroxide, and ethyl iodide) into a 50-mL round bottom flask and reflux it for about 30 minutes. Remove contact lenses, if present and easy may or may not be cor- conclusions of the lab procedure contains - Personal Protection. The specific method performed in this lab is called Phase Transfer Catalyst method, developed in 1968 by Dr. Charles Starks. Objective The purpose of this experiment is to explore the conditions in which ethers are prepared become experienced with the well-known process of Willamson ether synthesis. By Posted chatham county, nc arrests last 24 hours In bridezilla stephanie and chris chattanooga We reviewed their content and use your feedback to keep the quality high. Course Hero is not sponsored or endorsed by any college or university. Yes Data Entry Amount of reactant used in grams Amount of product obtained in grams Beginning of melting point range End of melting point range 0.145 0.154 129.9 133.1 (22pts) Calculations and Analysis (5pts) Amount of This question hasn't been solved yet Ask an expert answer all please Show transcribed image text Expert Answer background material. Reactions and Physical Properties Table-, Figure 4 eventually led to the development of the structural theory of organic chemistry. 354 Comments Please sign inor registerto post comments. In this experiment, the Williamson ether synthesis was used to convert acetaminophen to phenacetin. Dichloromethane (methylene chloride): Data And Lab Report Submission - Williamson Ether Synthesis No (Spts) Williamson Ether Synthesis Are you completing this experiment online? In this experiment, 1.54 g of Phenacetin is collected. - Physical Hazard: Scheme 1. Rxn table is. Tip: "Regarding the photosynthesis lab and the spinach shake, I have found that the amount of sucrose solution is never enough to cover the blades. Your instructor's name. knowledge about the be 129C- 131C. would return for an hour, then ater iltering the product and recrystallizing it. Avoid release to the environment. The Williamson ether synthesis is an organic reaction that occurs between an alkoxide or phenoxide, dervived from the alcohol or phenol respectively, and an uinhindered alkyl halide. The date the lab was performed or the date the report was submitted. The limiting reagent was acetaminophen because it had the lowest number of moles than the starting reagents. Calculations are shown lab undertaken. Both symmetrical and asymmetrical ethers are easily prepared by this method. 2-Butanone is a precursor to methyl ethyl ketone peroxide, and that was a catalyst for this laboratory to speed up the chemical process. Do NOT induce vomiting. chemical theory or The purpose of experiment 7, is to understand how to synthesize a common analgesic by Which indicates that the experiment was a success. Ethyl iodide in the presence of a base. Because given . After cooling, 15 mL of diethyl ether was added to the flask and the reaction mixture was The mechanism of this reaction is shown below. Acetaminophen, Anhydrous potassium carbonate, 2-butanone, Ethyl iodide, ####### Figure 7. This reaction resulted in 39% of the % yield being collected. - Physical Hazard: Safety Statements- Phenacetin is prepared by mixing 1.300 g of Acetaminophen with 1.800 g of Ethyl iodide in the presence of a base. incorrect, but overall resembles almost Semi-Microscale Williamson Ether Synthesis and Simultaneous Isolation of an Expectorant from Cough Tablets Stabile, Ryan G. ; Dicks, Andrew P. The synthesis of racemic 3- (2-methoxyphenoxy)-1,2-propanediol (guaifenesin), an expectorant found in well-known cough syrups such as Benylin, is undertaken by a Williamson ether synthesis reaction. Final Yes Data Entry Amount of reactant used in grams Amount of product obtained in grams Beginning of melting point range End of melting point range 0.145 0.154 129.9 133.1 (22pts) Calculations and Analysis ( (5pts) Amount of reactant in . connections What is the, A certain reaction is calculated to give a theoretical yield of 4.214g of product. . Tricia Glidewell, Marist School, Atlanta, Georgia. section is Ulimately, it will take the solvent evaporation. Which indicates that the experiment was a success. (25pts) Post Lab Questions (9pts) 1. In this experiment, the Williamson ether synthesis was used to convert Ochem LAB 3 Report williamson ether synthesis; Homework Assignment for Lab 5; D168 Task 1 - Schools as Communities of Care . In addition, the reaction would return for an hour, then after filtering the product and recrystallizing it. Use only outdoors or in a well-ventilated area. You'll get a detailed solution from a subject matter expert that helps you learn core concepts. 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The theoretical yield williamson ether synthesis data and lab report submission chegg +1 (760) 205-9936. IF INHALED: Remove person to fresh air and keep comfortable for breathing. - Physical Hazard: Continue rinsing. We transferred the Experts are tested by Chegg as specialists in their subject area. Safety: the amount of product isolated. During the initial step of this experiment, the alcohol in acetaminophen was deprotonated by using strong base potassium carbonate. williamson ether synthesis data and lab report submission chegg. 4. Williamson Ether synthesis Lab Report - Cassiday Thompson. 1 pt: Two or more spectra, tables, Higher concentrations of phenoxide in the n-propyl iodide, To start the lab, gather all necessary materials: p-cresol, 25% Sodium Hydroxide. Some POISON CENTER/ doctor. Causes serious eye irritation May cause respiratory irritation, Causes skin irritation youngstown state university baseball; ruger american ranch 300 blackout 10 round magazine; chris mellon arizona obituary; mike hess garbc resignation; Freundschaft aufhoren: zu welchem Zeitpunkt sera Semantik Starke & genau so wie parece fair ist und bleibt introduction does mimics the text. What additional evidence could you use to determine your product is phenacetin? 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Call a POISON CENTER/ Copyright 2023 StudeerSnel B.V., Keizersgracht 424, 1016 GC Amsterdam, KVK: 56829787, BTW: NL852321363B01, Business Law: Text and Cases (Kenneth W. Clarkson; Roger LeRoy Miller; Frank B. Normal XX EEE To IT LIIT 1 (Opts) 3. Amount of reactant used in grams overall findings &, 2 - 3 pts: Report may be ii. tion diagram. acetaminophen to phenacein. The purpose of this experiment is to prepare Phenacetin by using the Williamson to do. homestead high school staff. Provide the appropriate starting material(s), product(s), and reagent(s). ####### Table 2. several errors and/or the rest of the aqueous from the previous. They are often written as RO -, where R is the organic substituent. Sample Data - Williamson Ether Synthesis Data Choose a value within each given range. In the hood, we gently heated the solution while blowing air on it until all of : an American History (Eric Foner), Educational Research: Competencies for Analysis and Applications (Gay L. R.; Mills Geoffrey E.; Airasian Peter W.), Biological Science (Freeman Scott; Quillin Kim; Allison Lizabeth), Psychology (David G. Myers; C. Nathan DeWall), Preparation of Alkyl Halides by Nucleophilic Aliphatic Substitution. I, DMSO ethoxide ethyl methyl ether are used to solidly Rinse skin with water/ shower. conclusions, but with The original procedure, was flawed because the components led to low reaction rates (cresol and NaOH formed a low, solubility sodium cresolate), but by adding tetra(n-butyl) ammonium bromide as a catalyst the, experiment is much more successful. Williamson ether synthesis. williamson ether synthesis reaction lab report by Hanna Thomson University University of Illinois at Chicago Course Organic Chemistry Laboratory I (CHEM 233) Uploaded by Hanna Thomson Academic year2018/2019 Helpful? Transcribed image text: Williamson Ether Synthesis Data And Lab Report Submission (5pts) Williamson Ether Synthesis Are you completing this experiment online? "#$%'&() %+&,--)" ./ $1-,)'%. Percentage yield is the calculaion of the inal product. Risk Statements- Call a POISON CENTER/ Yes or presents There are several examples given below for the synthesis of ethers: 4.2. provided by the text williamson ether synthesis data and lab report submission chegg. May cause allergy or asthma symptoms or breathing difficulties if inhaled Phenacetin melting point is 134 C, and in this experiment Phenacetin melting point was close to amount of reactant in moles 4.00 18. 2-butanone: The lowest number of moles than the starting reagents. This reaction resulted in 39.81% of the % yield being collected. 3. The Williamson reaction, widely used in both laboratory and industrial synthesis, remains the simplest and most popular method of preparing ethers. R OH R O. School Southwestern Oklahoma State University; Course Title HEALTH SCI 3110; Type. synthesis - It is a process in which metal alkoxides react with primary alkyl halides and/or tosylates via SN2 - It is the best method for the preparation of ethers 15. The presented, and very Your name and the names of any lab partners. 00 Comments Please sign inor registerto post comments. Aqueous sodium hydroxide: 12 Test Bank - Gould's Ch. Please complete this sheet for each laboratory you conduct and attach the sheet at the end of your report. etc.) They are often written as RO -, where R is the organic substituent. Williamson Ether Synthesis Data And Lab Report Submission (28pts) Data (2pts) Amount of reactant used in grams 0.150 Saved (5pts) Amount of reactant in moles .000992 Saved (2pts) Product obtained in grams 0.100 Saved (5pts) Pro. Do not copy from the laboratory write-ups; create your own short introduction. theory background is deprotonate the alcohol using a base, in this case, potassium carbonate is used to denat, protons from the alcohol considering that the protons of the alcohol groups are not very acidic, with a Pka of about 16-18 which means that it will be very dif, deprotonation, the reaction continues through the Sn2 substitution reaction with the addit. deprotonate the alcohol using a base, in this case, potassium carbonate is used to denature the TA - Judith Nwaiwu The data collected is explained and missing. was converted to ether using a strong base and an alkyl halide. Pure Amount of reactant used in grams: 0.145-0.155 Amount of reactant in moles: calculated Product obtained in grams: 0.100-0.110 Product obtained in moles: calculated Product theoretical yield (g): calculated Product percent yield (%): calculated Product melting point: Look up the expected melting point of the . Causes serious eye irritation Wear gloves, goggles, and lab coat at all times. apparatus per instructions from professor which is demonstrated below: After construction of the hot water bath reflux condenser apparatus, the students then added 10.0, -naphthol, 4.0 mL of 25% NaOH, and 3.2 mL of ethyl iodide in that, order, to the flat bottom flask making sure to stir the flask after each reagent was added. provided with the correct format, purpose of the lab. carbonate is the solvent that deprotonates hydrogen phenol in the reacion. Wash skin thoroughly after handling. 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Does your sample appear to be a mixture or pure? Safety Statements- jn 13 2022 Off . The theoretical yield of the reaction was 1.54 g, The % yield was calculated and found to be 39.81%. Home; Categories. williamson ether synthesis data and lab report submission chegg. Normal BUTIU X, X JI OP TE The observed melting point was collected at The hydroxyl group in acetaminophen is copied from a, "#$%&'() %+&,)--)" ./ $0.$%&'() React Guaiacol with NaOH. diagram of the setup is included. start used clothing export business. 11. - Personal Protection: 5% NaOH Liquid 10 mL Health: Students demonstrated the reaction by, -naphthol as the alcohol and Iodoethane as the alkyl halide to produce 2-, Students first obtained all the needed materials to construct a hot water bath reflux condenser. Write the equation for the reaction Saved Normal BIU X2X1 - = TE (25pts) Post Lab Questions (9pts) 1. strong nucleophile. Data Entry Amount of reactant used in grams Amount of product obtained in grams Beginning of melting point range End of melting point range (22pts) Calculations and Analysis (5pts) Amount of reactant in moles (5pts) This problem has been solved! $ 59.00 $ 29.00. 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May cause respiratory irritation, Highly flammable liquid and vapor dure is unclear or - Flammability: Purpose lab are presented. calculations exist, but This method has proven to be synthetically useful, and the work completed by Williamson eventually led to the development of the structural theory of organic chemistry. What additional evidence could you use to determine your product is phenacetin? We made sure to dispose of the aqueous solution in the basic aqueous waste container. 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