FMC Corporation 2929 Walnut Street Philadelphia, PA 19104 (215) 299-6000 (General Information) . Examination of urine, blood and faecal levels of vitamin B 1 during microcrystalline cellulose ingestion showed no difference from control periods (Anonymous, 1966). If you are already a ChemPoint customer then sign up for access to our online ordering website. MATERIAL SAFETY DATA SHEET Avicel RC/CL Microcrystalline Cellulose and Sodium Carboxymethylcellulose MSDS Ref. Similarly, the European Food Safety Agency has also evaluated Microcrystalline cellulose and established that it is not absorbed systemically and excreted unchanged. The highly reactive amorphous regions selectively hydrolyze, releasing the crystallites, which are subsequently mechanically dispersed. Pharmacel 112 can be used in a wide range of oral solid dosage (OSD) forms as binder, compressing agent . AVICEL RC 581. Avicel Microcrystalline Cellulose: Chemical Identifiers. In many applications, one METHOCEL product can perform the job of two, three or even more ingredients saving money and time. This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication Pharmacel 112 is a directly compressible microcrystalline cellulose grade with a low moisture content (LOD Max. Product Name: Microcrystalline Cellulose 1.2. Manufacturer: FMC BioPolymer. The formed cellulose molecules pack themselves closely to each other, stabilised through hydrogen bonds, creating crystalline regions interspersed with amorphous regions. They are white to off-white, free-flowing hydrophilic powders supplied in a variety of viscosity grades corresponding to approximate molecular weight, ranging from 100,000 to 7,000,000 daltons. Cellulose microcrystalline Revision Date 25-Dec-2021 SARA 313 Not applicable SARA 311/312 Hazard CategoriesSee section 2 for more information CWA (Clean Water Act) Not applicable Clean Air Act Not applicable OSHA - Occupational Safety and Health Administration Not applicable CERCLA Not applicable California Proposition 65 This product contains the following Proposition 65 chemicals. CAS #: 9004-34-6 . JRS Pharma: PROSOLV SMCC 90: Microcrystalline Cellulose, Colloidal Silicon Dioxide: 125: 0.25 - 0.37: Formulas in which a balance of flow and compaction is required. Copyright 2023 by International Flavors & Fragrances Inc. IFF is a Registered Trademark. Avicel PC 611 Microcrystalline Cellulose. PDF (4.11 mb) Footer menu 1. This is unlikely to be a problem when Microcrystalline cellulose is consumed as part of a medical product where it is used as an excipient in the formulation. %PDF-1.4 stream Learn about FMC's industry leading goal of net-zero emissions by 2035. Since cellulose contains both amorphous and crystalline regions, when the crystalline regions are mechanically and chemically isolated and elaborated, various useful ingredients in the form of cellulose crystals are obtained, one of which is Avicel Microcrystalline cellulose. There have always been two different points of view for the liquidity of MCC. The chemical structure of cellulose is shown below: In the biosynthesis of cellulose, two molecules of -D-glucose molecules combine via a condensation reaction (elimination of one molecule of water) to form the so-called cellobiose unit. Product and Company Identification . : 5 This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication Standard, 29 CFR 1910.1200 and Canadas Workplace Hazardous Materials Information System (WHMIS) requirements. JRS Pharma: PROSOLV SMCC 90 LM: Microcrystalline Cellulose, Colloidal Silicon . All rights reserved. Microcrystalline Cellulose Side Effects. Description:Chemical PropertiesMicrocrystalline cellulose is a purified, partially depolymerized cellulose that occurs as a white, odorless, tasteless, crystalline powder composed of porous particles. GENERIC EU MSDS - NO COUNTRY SPECIFIC DATA - NO OEL DATA 1. vdZ@Rgl{eU+7N!3!|hUmW)~}U*7k i@j)q["MEydtP"ftFu]t }JN~A"8lz7#}J.i@ qaj/QU<5OrVMfl{pL? Cellulose microcrystalline for column chromatography. Unique functionality for a broad range of pharmaceutical applications. The polymers added organosolubility further creates advantages for employing HPMC in solvent spray-drying applications. It is, however, a good source of fibre. Remove The smallest units, the elementary fibrils (cellulose crystalline strands) are made up of many -(1-4) glucose chains which are bundled to form microfibrils. Report Category. Molecular weight: Not Applicable 1.5. "l%I-*j|-)@ EtG[TQd%8,.fg4QqH'-dV ?3Z#GK# dGnF7x*3yY\VUwPhmyYT@f67Zcsmdi!%94K@:L# vJeU-kzRT-(YX/fKC Fmc Corporation: Ultra-fine microcrystalline cellulose compositions and process . %PDF-1.4 All Rights Reserved. F. Lerk, G.K. Bolhuis, A.H. De Boer, Effect of Microcrystalline Cellulose on liquid penetration in and disintegration of directly compressed tablets, Journal of Pharmaceutical Sciences, 68 (1979) 205-211. Generally, these can be classified into two broad groups: Standard grades, and Co-processed grades. Solid dispersions are one of the key technologies for formulating oral solid dosage forms containing APIs with bioavailability challenges. Powder becomes slippery when wet. Avicel PH-101. Microcrystalline cellulose is an exceptional material and one of the most widely used excipients in the pharmaceutical field. X\o^ Microcrystalline Cellulose, Colloidal Silicon Dioxide: 50: 0.20 - 0.30: Best in class binder. endobj P}MFbN#[>r(y F. Steele, M. Tobyn, S. Edge, A. Chen & J. N. Staniforth.Physicochemical and Mechanical Evaluation of a Novel High Density Grade of Silicified Microcrystalline Cellulose, Drug Development and Industrial Pharmacy, 30:1 (2004), 103-109. on Avicel microcrystalline cellulose, the most trusted excipient brand for decades. FMC Corporation. Cellulose microcrystalline MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents. Watch Now. As some of the data above show, microcrystalline cellulose possesses unique physicochemical properties that set it apart from native cellulose. The data shown below apply only to Avicel PH 101. /PRNewswire/ -- ReportsnReports added Global Microcrystalline Cellulose (MCC) Market Growth 2019-2024 to its online research database. endstream (1962). ECOLOGICAL INFORMATION ECOTOXICITY Practically nontoxic to fish: Rainbow trout LC50 (96hr) > 100%, saturated solution (Microcrystalline cellulose, Avicel PH-101) PERSISTENCE AND BIODEGRADABILITY Inherently biodegradable. You have already flagged this document.Thank you, for helping us keep this platform clean.The editors will have a look at it as soon as possible. In the late 1960s, Avicel Microcrystalline cellulose was registered in the supplement to the National Formulary as a pharmaceutical excipient. Looking for FMC'searnings news? It is a white, free-flowing powder. Revision No. Foam Booster/Stabilizer; Rheology Modifier; Stabilizer-Emulsion; Suspending Agent . Upon ingestion, microcrystalline cellulose is not absorbed into the blood stream and therefore has little toxicological potential. Microcrystalline cellulose is a commonly used excipient in the . . /Producer(Sub Systems, Inc.)/CreationDate(D:20181207095625+05'00')/ModDate(D:20181207095625+05'00')/Creator(Sub Systems, Inc.) The product would later go on to be commercialized under the brand name Avicel by FMC Corporation. Product Specifications: Chemical and Physical: Loss on drying, % NMT 6.0* Viscosity, cps, 1.2% solids, 120 sec 39 to 91 . No. Combinations of microcrystalline cellulose (MCC) and sodium carboxymethyl cellulose (Na-CMC) are commonly used as stabilising agents and suspending agents in pharmaceutical formulations. << iQuLyI4D@yq#u0dZt=0?QUz{K6by_C"vW~Nj$bo? Dupont acquired the microcrystalline cellulose business of FMC Corporation in 2017. Are you sure you want to delete your template? Microcrystalline Cellulose. Avicel Microcrystalline cellulose is composed of insoluble fibre and does not contribute any other material of nutritional importance. gwf;J(e0o|1p{R~P^);ao!%{0KD7. Avicel CL-611 Microcrystalline Cellulose and Sodium Carboxymethylcellulose Page 1 of 9. Microcrystalline cellulose 9004-34-6 <1 Synonyms are provided in Section 1. (AEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEM %)piQpFNnFu\4m4( ESE;m& %QL((((((((((((((((((((((((((((((((((((((((P3NhC To help, weve put together a simple guide for selecting Avicel Microcrystalline cellulose grades, with simple explanations of some of the most common grades, plus recommendations that will serve the majority of buyers. Enter your [postal] code to see information about local products, representatives and retailers, along with special offers in your area. 4. Interestingly, the discovery of Avicel was accidental, the team was attempting to break up hydrolysed cellulose using a Waring Blender. These include amphiphilicity, a higher degree of crystallinity, surface area, higher hydration properties, and morphology. : CL-611NF Date Approved: 01/13/2010. Carboxymethyl Cellulose Sodium N/A Nutrition & Biosciences www.pharma.dupont.com HO 00017 - 0 E L 02.2020 www.dupontnutritionandbiosciences.com . Microcrystalline Cellulose / Avicel PH-102. << Microcrystalline cellulose -The oldest polymer finds new industrial uses,. Material Safety Data Sheet or SDS for Microcrystalline cellulose 9004-34-6 from chemicalbook for download or viewing in the browser. PharmaCentral 2021 . undefined. Regulatory Information GRINDSTED Xanthan Gum is a naturally fermented product of carbohydrates and is applied in various liquid, semi-solid and solid pharmaceutical dosage forms. METHOCEL products have been in continuous production for more than 70 years with production facilities and deep product expertise located around the globe. Microcrystalline cellulose has excellent compressibility properties and is widely used in solid forms such as tablets that are hard, but can dissolve quickly, and this has increased its demand in . Terms and Conditions Compliance Solutions Industries About 3E News & Events . Tel: 1-239-598-5088 [email protected] www.espllc.us. Patel, F. Podczeck, Investigation of the effect of type and source of Microcrystalline Cellulose on capsule filling, International Journal of Pharmaceutics, 128 (1996) 123-127. Microcrystalline cellulose (MCC) is a pure partially depolymerized cellulose synthesized from -cellulose precursor (type I), obtained as a pulp from fibrous plant material, with mineral acids using hydrochloric acid to reduce the degree of polymerization. SCMm_>x^O9l (n. The charts below provide guidance on how to select and use standard and co-processed grades of Avicel Microcrystalline cellulose in pharmaceutical products. However, with many different grades (standard and specialty) on offer, how do you select the correct material for your needs? % 1 0 obj Avicel Microcrystalline cellulose is manufactured in the United States of America by Dupont. Chemical Formula: (C6H10O5)n 1.4. Cellulose microcrystalline. They are high molecular weight, highly sulfated, linear molecules with a galactose backbone. Alginates also function as actives in some anti-reflux products. /MediaBox [0 0 612 792] : 160182 Date Approved: 05/25/2010 Revision No. They are differentiated from each other by the amount of 3,6-anhydrogalactose as well as the number and position of ester sulfate groups present. 130. stream <> However, it yields non-digestible fibre. It does not interfere with other nutrients when added to food products, and is instead, an excellent carrier and stabiliser, helping prolong the viability of food products. 2008-2023 ChemPoint. This Microcrystalline Cellulose . Protect them from sunshine or rain. Alginates from IFF are an excellent choice for consistent performance in a variety of applications. The figure below illustrates the structural organisation of cellulose within plants. Avicel Microcrystalline Cellulose: A Guide to Grades and Uses, Working Hours (Mon to Friday): 08:30 - 17:30, legendary Canadian-born chemist, Orlando Aloysius Battista, United States Pharmacopoeia and National Formulary, United States Food and Drug Administration, Quantitative nutritional analysis of Avicel Microcrystalline cellulose (in 100g), https://doi.org/10.1016/0378-5173(95)04231-8, https://doi.org/10.1016/j.ejpb.2004.05.009, https://doi.org/10.1002/9783527682935.ch04, Pharmaceutical Acronyms and Abbreviations, Glossary of Terms Used in the Pharmaceutical Industry, Standard Terms & Conditions Of Sale Of Goods And Services, 4-O-[(1S)-hexopyranosyl]-D-glycero-hexopyranose. Alubra sodium stearyl fumarate from IFF Pharma Solutions is a comparatively hydrophilic lubricant widely used in capsule and tablet formulations. Of all the different brands and grades of MCC, Avicel PH 101 or Emcocel 50 has been the most widely used. (Microcrystalline Cellulose) DATE PREPARED: 1/7/2016 Page 1 of 4 Section 1. It should be noted that native cellulose itself is completely indigestible, and its hydrolysis during the production of microcrystalline cellulose does not alter its behaviour in the intestine. It is hygroscopic and insoluble in water. In summary, Avicel microcrystalline cellulose is virtually inert, its energy content is very low or zero and it is not absorbed. G2W4de=u183KGH{ vQ#4:1\wc Chemical Formula: (C6H10O5)n 1.4. /Resources 2 0 R Fiber supplements can lessen the absorption of some . The product range encompasses methylcellulose and hydroxypropyl methylcellulose (hypromellose) each available in different grades to address a wide range of applications including tablet coatings, granulation, controlled release, drug layering, vegetarian hard-shell capsules and amorphous drug stabilization. Studies from the World Health Organisation and the European Food Safety Agency have concluded that Microcrystalline cellulose has no safety concerns for the public when used in animal nutrition. Avicel Microcrystalline Cellulose is a safe and non-hazardous material that is widely used in pharmaceutical formulations and food products (as a bulking agent and to add crispness). Microcrystalline cellulose (C6H10O5)n is refined wood pulp. The application areas for Avicel Microcrystalline cellulose are immense and encompass many industrial sectors such as food, pharmaceuticals, and cosmetics. Low use levels of GRINDSTED Xanthan Gum are sufficient to provide desired viscosities and textures. Microcrystalline Cellulose; Cellulose; Functions. Further elaborations can then be performed on the obtained material to produce many other grades of Microcrystalline cellulose. Gloves, eye protection and a dust mask should be used. Microcrystalline cellulose was negative in the Ames mutagenicity assay [FMC Study Number I91-1189], and caused no gac74 [#B6`Wnw7 Frijlink, Compaction mechanism and tablet strength of unlubricated and lubricated (silicified) Microcrystalline Cellulose, European journal of Pharmaceutics and Biopharmaceutics, 59 (2005) 133-138. Microcrystalline cellulose (MCC) is one of the most important tableting excipients thanks to its outstanding dry binding properties, enabling the manufacture of tablets by direct compression (DC). The table below lists the most important chemical identifiers applicable to Avicel Microcrystalline cellulose. EINECS #: 232-674-9 1.7. Molecular weight: Not Applicable 1.5. Biologicals by FMC. Avicel PC 611 (FMC Biopolymer) . ;(Imu9Jv_ YhnHTbwP*:mg"T{BO;!QR e,cqO! (&E. If you have Crohn's disease or a history of bowel obstruction, discuss with a doctor or pharmacist about drug interactions with fiber supplements.. Note that Avicel Microcrystalline cellulose is available in different particle sizes and moisture grades that have different properties and applications. As one of the most robust and efficient excipients, it tolerates high salt content, high temperature and is stable in a wide pH range. It is . Date Approved: 05/25/2010. Battista, O. 8 0 obj Combines good flow and high compactibility. <> CAS #: 9004-34-6 Find answers in our support articles. >> >z+{!A6wy @nLK3R#hRn sba3;b61V:#Z3X,*?RC!wPmqd7WkA'aZMt6PFV3SEvlY'=p.mn[I{puc\6'ZIyI%rD'zA!"t3I2F ^R;LK,?:&THv*y^K> o0Af?J9J-{s2&cCn)32ADzl%sS5O~J[ It is highly versatile and is therefore also widely used in topicals and semi-solid & liquid dosage forms, including ointments, creams, gels, pastes, solutions, suspensions, and emulsions. Delivering efficient and robust formulations. METHOCEL cellulose ethers are water-soluble polymers derived from cellulose. endobj The cellulose molecule is formed through repeated condensation of cellobiose units. ETHOCEL premium ethylcellulose resins are water-insoluble polymers. ]2}Sb2Wdn-;^}n(/;r\'l3--l~ kuI?H>$7;!l|g|i4&dtb/O3!C!#\qpg+>Q0OM Co-processed excipients deliver functional synergies to address formulation challenges with simplified, single ingredient solutions. Microcrystalline cellulose is produced by subjecting to a high shear treatment, at elevated temperature and pressure, a reaction mixture of a cellulose material, an active oxygen compound and water, for a time effective to depolymerize the cellulose material. POLYOX resins are nonionic polyethylene oxide solubility polymers. More sophisticated drug discovery techniques have led to pipeline compounds that require solubility enhancement to be therapeutically effective. X]s ;/4'OslUK:|QY`IL|w @ I!*2T~IN?*}y2*49]yOQ*VG%Gu,;&9zE{q==xvrv}rd(yG*qN6E0K$IBWhe Microcrystalline Cellulose E460 MSDS 1. SEM micrographs of microcrystalline cellulose (MCC) models with a scale bar of 100 m [1] . $4%&'()*56789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz ? Microcrystalline cellulose is a term for refined wood pulp and is used as a texturizer, an anti-caking agent, a fat substitute, an emulsifier, an extender, and a bulking agent in food production. Slightly soluble in 5% w/v sodium hydroxide solution; practically insoluble in water, dilute acids, and most organic solvents. };khd5x=fr The main source of cellulose is woody plants, since it is the main building block of the cell walls of higher plants. PDF (2.77 mb) 2021 FMC Sustainability Report. GRINDSTED Xanthan Gum readily dissolves in water under ambient conditions without the need of special high-shear equipment. Test Data Available. J]3yzZ2Z$mZ7o%-Xyq'()V9KX0gk~AA Cu:3(]N"AQdUt~h|P Medium size standard MCC grade, suited for the majority of directly compressible actives. Have an order or account question, find answers in our Online Support articles. Avicel Microcrystalline cellulose also serves as a moisture adsorbent and as a general-purpose formulation improver. Buy Chemicals. MATERIAL SAFETY DATA SHEET Avicel PH Microcrystalline Cellulose MSDS Ref. Dyvo5bp#bR W7~IF C" d6zLz~!#>@HO}sx;hm>> lH5JWy}DgKRR"Fs CAS #: 9004-34-6 1.6. Performing this action will revert the following features to their default settings: Hooray! PRODUCT AND COMPANY IDENTIFICATION PRODUCT NAME: Avicel PC 611 Microcrystalline Cellulose CHEMICAL FAMILY: Carbohydrate, Cellulose Derivative SYNONYMS: Microcrystalline cellulose (INCI name): MCC, cellulose gel; Sodium Carboxymethylcellulose: NaCMC, CMC, SCMC, Carboxymethylcellulose GENERAL USE: Personal Care MANUFACTURER FMC BioPolymer 1735 Market Street Philadelphia, PA 19103 (800) 526-3649 (General Information) [email protected] (Email - General Information) FMC Europe NV Avenue Mounier 83 1200 Brussels, Belgium 353 21 435 4133 (General Information - Cork, Ireland) 2. Innovation is at the heart of IFFs purpose of applying science and creativity to create a better world. We know that our customers need to provide reliable and consistent products to their patients. EMCOCEL 90 M. 130. Packaging: 34 x 50 kgs fiber drums. Ui[(lY[|//o)ZmqbQT-Y.M|se[)m?(WRV.W8J/j}9>X.VNsZNOp'^14nuXM%rea5]@ MKnNe /Group << /S /Transparency /CS /DeviceRGB /I false /K false >> This paper is based on a study of the interactions that take place during the process of hydrogel formation, break down, and recovery. Alginate drug delivery harnesses the unique properties of seaweed for premier performance in multiple pharmaceutical and nutraceutical applications; they impart viscosity in solutions and even form a three-dimensional gel in the presence of calcium ions. Quick Links. By utilizing proprietary co-processing technologies, Dupont also manufactures LATTICE NTC products. Avicel CL-611 Microcrystalline Cellulose and Sodium Carboxymethylcellulose Manufacturer FMC Corporation Product code 103-B Revision date 2014 September 30 Language English. The aqueous solution to barrier membrane coating. /Type/Page Validity Area. < gV2@o2s&WS@Et%Up:`U '_ h?8qyP=&> GFprm9A!uu1 }&*kQ c^&eX}^K}h9YCb2L(yL):,+g8_u. A family of polysaccharide products that allow distinctive drug delivery solutions. 6 0 obj Avicel is one of the best-known pharmaceutical excipient brands and, without doubt, one of the most frequently used raw materials in solid oral product formulation and manufacture. Thus, Avicel contributes no or very few calories to the food system. . Place an order online, track your orders, download SDS and TDS, and see your quotes, all in one secure place. The United States Food and Drug Administration considers microcrystalline cellulose a safe material for all animal species. In Cellulose and Cellulose Derivatives in the Food Industry, T. Wstenberg (Ed. LATTICE Microcrystalline Cellulose by Dupont, is an alpha cellulose obtained from naturally ocurring cellulose found in wood pulp, which is an equal structuring polysacharide that is found on fruits and vegetables. Are you looking for information about products and services by region? LATTICE Microcrystalline Cellulose has many important uses within the food, pharma, specialty applications and industrial such as non-stick coatings, insulation of wiring, crop protection and paints,coats and inks. q86@on$^X_HuH;3` Synergies to simplify formulation challenges and reduce operational costs. The table below lists the typical nutritional information of microcrystalline cellulose: Quantitative nutritional analysis of Avicel Microcrystalline cellulose (in 100g)1. PROSOLV SMCC, silicified microcrystalline cellulose, is a unique combination of microcrystalline cellulose (MCC) and colloidal silicon dioxide (CSD).A high functionality and multifunctional excipient, it requires less complex processing, has high inherent functionality, and passes that functionality on to the drug formulation. MATERIAL SAFETY DATA SHEET Avicel PC 611 Microcrystalline Cellulose Page 1 of 8 MSDS Ref. Within the pharmaceuticals field, where the bulk of this material is utilised, Avicel Microcrystalline cellulose functions as a filler and diluent, dry binder, flow, disintegrating, and compression aid in tablets, capsules, and granules. Its used in capsules and tablets, both in wet granulation and direct compression processes, where it serves as a moisture adsorbent, tablet, and capsule diluent, and tablet disintegrant.It is also widely used as a supplementary formulation aid, primarily to enhance the . Description: Microcrystalline Cellulose is a term for refined wood pulp manufactured through plant fibre hydrolysis. Document(s): certificate data msds. Safety Data Sheet (SDS) Viewer. q9;v80 <> 10.1 Future Forecast of the Global Microcrystalline Cellulose Market from 2023-2028 Segment by Region 10.2 Global Microcrystalline Cellulose Production and Growth Rate Forecast by Type (2023-2028 . The range of products includes three basic types of carrageenan kappa, iota and lambda from various species of red seaweed. Aqueous suspensions of microcrystalline cellulose have . endobj 2021 Annual Report. When selected in wet granulation, the optimum level of use is between 5 and 20%, although higher levels have been successfully used. <> II: effects of changes in the content of Microcrystalline Cellulose, AAPS PharmSci, 2 (2000) 45. Stabilizer composition of co-attrited microcrystalline cellulose and carboxymethylcellulose, method for making, and uses CN103842425B . . : 9004-34-6 1.2 Relevant identified uses of the substance or mixture and uses advised against YUMPU automatically turns print PDFs into web optimized ePapers that Google loves. "R}~Q:~pgg'"l/O:OV~ @zo7g;)K;=d'}z8}7w7?Iuw?w~ikK^^'d4k;g_u_LOC6($uiz["Dw#j{ogw~0B"ty'{DqXmImPiww#({LDo^/w;?EW>;b$l/fmQ-1GG/jls}>N\UbZWi,`:O?e;hD8}uC?L{yiD>_2?0 :f =eU}|r=r?P5){{o:tzY- F kNdOaM;p0Nmm7A!Va/eWzgT5vw Ur?0J. Product Name: MICROCRYSTALLINE CELLULOSE Date/ Revised: 27/November/2012 Page 1 of 4 1. CAS 9004-34-6. \C[i+rY2$V,,WT#_)3K?=/fW%[,lE"V?C PipEAz_xO;`cZsC0qcx;@tp]c*T7ge @Mty?]@SNmpf/]q#I,G1I?SR.@z*Xb KjR hb{T$CQrr Yx%O@~57eL5S\r-|EZ)Y.C]KuIlW]@12KY,S]C"e%b*|YX122igjl; @! ,}b;XQ})+l{~d_=sUtl V"CbKas+;fc>]bt#F,Md]]!5xae ;}rr^NI]rUc^,5Lc(fyyp*a=~U}WveuTLYX/ _V{#* g(*Rrm0gyv9i@0UT:A+{eW/y BS3_!Qv rt^BN! MATERIAL SAFETY DATA SHEET Product Name: MICROCRYSTALLINE CELLULOSE Date/ Revised: 27/November/2012 Page 4 of 4 15. MSDS Ref. Browse Avicel PH-101 and related products at MilliporeSigma. At the same time, its pronounced shear-thinning behavior enables handling of even highly viscous solutions. endobj Millipore. IDENTIFICATION OF THE SUBSTANCE/PREPARATION AND THE COMPANY/UNDERTAKING Material Name: Estradiol Tablets Trade Name: RONFASE . 3 0 obj Your file is uploaded and ready to be published. microcrystalline cellulose and carboxymethylcellulose sodium NF, Ph. IFF has decades of experience controlling these naturally derived materials, which means you can count on consistent performance, every time. ChemicalBook. Chemical Name Microcrystalline cellulose (INCI Name): MCC, cellulose gel Common Name Avicel PH105 Microcrystalline Cellulose CAS Number 9004-34-6 Impurities and/or Stabilizing Additives No data available Section 4: First Aid Measures General Advice No data available If Inhaled Remove person to fresh air. Product name: Microcrystalline cellulose; CBnumber: CB4217972; CAS: 9004-34-6; EINECS Number: 232-674-9; Synonyms: MICROCRYSTALLINE CELLULOSE,cellulose; FMC has deep roots in the food production system worldwide learn more about our latest advances in the future of agriculture. 1.3. q9;v80q>jZ In extrusion-spheronisation, it is the excipient of choice. Description: Microcrystalline Cellulose E460 is a term for refined wood pulp manufactured through plant fibre hydrolysis. The wood pulp is depolymerized by acid hydrolysis and turned from a fibrous material to a white freely-flowing powder. % This unique functionality can be used in a diversity of applications such as controlled release dosage forms, enteric coatings, microencapsulation and stabilization in solutions and suspensions. Molecular Weight null. >> United Nations Sustainable Development Goals, Alginates Protanal, Manucol, Protacid and More, Barrier membrane, Controlled release hydrophilic matrix, Taste masking, Carrageenan Gelcarin, Viscarin and More, Controlled release hydrophilic matrix, Muco-adhesive, Rheology modifier, Rheology modifier/stabilizer, Thin films, Rheology modifier, Rheology modifier/stabilizer, Binder, Controlled release hydrophilic matrix, Rheology modifier, Rheology modifier/stabilizer, Shell - hard capsule, Tablet coatings, Thin films, Topical, Capsules, Other, Solutions, Suspensions, Tablets, Controlled release hydrophilic matrix, Hot melt extrusion, Muco-adhesive, Osmotic pump, Muco-adhesive, Rheology modifier, Rheology modifier/stabilizer, Thin films, Topical.