And youll usually keep coughing up mucus. loss of appetite. You should stop taking these medications 2 weeks before you start Trelegy Ellipta treatment. GlaxoSmithKline. It also helps keep the drug from harming the environment. Serious side effects and their symptoms can include: Note: Long-acting beta2-agonists (LABAs) are known to increase the risk of asthma-related death and hospitalization if theyre taken alone. This will help to keep you free of symptoms for about 24 hours. Youll take one inhalation (puff) of the medication once a day. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. COPD is a long-term disease in which the airways and air sacs inside the lungs become damaged or blocked, leading to difficulty breathing. The word Ellipta refers to the specific type of dry powder inhaler that contains the drug. Breo is a brand-name prescription medication. Avg. Taking too much umeclidinium isnt likely to cause you any serious side effects. It is approved by the FDA for three uses: for the long-term maintenance of chronic obstructive pulmonary disease (COPD); for the daily maintenance treatment of airflow obstruction in patients with COPD; and for the maintenance treatment of asthma in adults. Keep the inhaler dry and away from heat and sunlight. It is primarily metabolized via CYP3A4 and is also a substrate of P-glycoprotein transporter. The official half-life of sildenafil is 3-4 hours after an oral dose in the range of 25mg - 200mg. Learn about side effects, warnings, dosage, and more. If you have questions about drug interactions that may affect you, ask your doctor or pharmacist. If youre not sure if youll need to get prior authorization for Trelegy Ellipta, contact your insurance company. It is mainly eliminated via the fecal route after an intravenous dose is given. Pulmonologist just switched me to Trelegy. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. This medication is also metabolized hepatically. With NiceRx, you'll only pay $49 to obtain your Trelegy Ellipta, regardless of the retail price. Trelegy Ellipta is made of three medications that work to help ease the symptoms of COPD. For patients who do not respond adequately to Trelegy Ellipta 100/62.5/25 mcg once daily, increasing the dose to Trelegy Ellipta 200/62.5/25 mcg once daily may provide additional improvement in asthma control. If youre sexually active and you or your partner can become pregnant, talk with your doctor about your birth control needs while youre using Trelegy Ellipta. The three active drugs in Trelegy Ellipta are fluticasone, umeclidinium, and vilanterol. For information about this, see the Trelegy Ellipta use with other drugs section below. Theres no human data available on whether the active drugs in Trelegy Ellipta pass into breast milk or how the drug may affect a child. This drug comes with several precautions. If your potassium level gets too low, you can have heart problems such as an irregular heart rhythm (a heartbeat thats too fast, too slow, or uneven). Do not take two doses at one time. Results showed a 25% reduction in the annual rate of flare-ups vs. Anoro, and a 15% reduction in the annual rate of flare-ups vs. Breo. Once opened, the inhaler expires in 6 weeks. Medically reviewed by Leigh Ann Anderson, PharmD. Trelegy Ellipta doesnt interact with alcohol. Use Trelegy Ellipta at the same time each day, and not more than once in a 24-hour period. They may be able to recommend a different diuretic. If you open and close the cover of the inhaler without inhaling the medication, youll lose the dose. Its important that even if you dont feel or taste your dose, you dont take another dose. It works by activating adenyl cyclase, which then catalyzes a reaction from adenosine triphosphate (ATP) to cyclic 3,5,adenosine monophosphate (cyclic AMP). Its used to treat chronic obstructive pulmonary disease (COPD) and asthma. For information about this, see the Trelegy Ellipta use with other drugs section below. They can recommend ways to help ease the pain. The studies showed that FEV1 in people who took Trelegy Ellipta was between 122 mL and 124 mL higher than it was in people who took fluticasone and vilanterol. In studies of patients with asthma, a significant improvement in lung function (FEV-1) was seen at 24- and 52-weeks when compared to the use of Breo (fluticasone and vilanterol). In animal studies, umeclidinium was seen in the breast milk of mothers who were given the drug. The actual price youll pay for either drug depends on your insurance plan, your location, and the pharmacy you use. Other drugs that may prolong your QT interval include: If you take any of these medications or other drugs for your heart rhythm, talk with your doctor before you start Trelegy Ellipta treatment. Instead, youll use a rescue inhaler for sudden trouble breathing. Off-label use is when a drug thats approved to treat one condition is used to treat a different condition. More recently, in 2020, the drug was approved to treat asthma. View complete list of side effects. Other combination medications that may be used to treat COPD include: Other medications that may be used to treat COPD include: Note: Trelegy Ellipta and the alternative drugs listed here are meant to be used over time to control COPD symptoms. Here are some examples of other drugs that may be used to treat asthma. Trelegy Ellipta is good for only 6 weeks after opening it or until the counter reads 0, meaning that no doses are remaining. There arent any herbs or supplements that have been specifically reported to interact with Trelegy Ellipta. They arent meant to be used for sudden breathing problems caused by asthma. Sharing this information can help you avoid potential interactions. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. For more information about Trelegy Elliptas approved uses, see the Trelegy Ellipta for COPD and Trelegy Ellipta for asthma sections below. Below are examples of these side effects. Instead, to treat a flare-up, your doctor will likely want you to use a rescue inhaler such as albuterol (Ventolin HFA, ProAir) or levalbuterol (Xopenex). The maximum recommended dosage is 1 inhalation of Trelegy Ellipta 200/62.5/25 mcg once daily. Even if you dont taste or feel your dose, dont take another dose. pain in the nose and mouth. Based on a survey for secondary outcomes, Trelegy also improved patients health-related quality of life when compared to Breo, which included items such as daily symptoms, daily activities and perceived well-being. For information about this, see the Trelegy Ellipta use with other drugs section below. These conditions affect your airways, making it hard to breathe sometimes. Trelegy Ellipta contains umeclidinium, which is a type of drug called an anticholinergic. Examples of rescue inhalers include albuterol (Ventolin HFA, ProAir) and levalbuterol (Xopenex). Symptoms of a mild allergic reaction can include: A more severe allergic reaction is rare but possible. These foil strips hold Trelegy Elliptas active drugs as follows: Note: After you inhale a dose of Trelegy Ellipta, be sure to rinse your mouth with water and spit out the water without swallowing. Slide. GSK Press Release. Here are some examples of other drugs that may be used to treat chronic obstructive pulmonary disease (COPD). Here are answers to some frequently asked questions about Trelegy Ellipta. How Long Does Trenbolone Takes Times To Stay In Your System? unpleasant or unusual taste in your mouth. Call your doctor for medical advice about side effects, precautions or warnings. If you develop symptoms of thrush, be sure to see your doctor. You may be able to. The safety of TRELEGY ELLIPTA in COPD is based on the safety data from two 12-week treatment trials with coadministration of umeclidinium and the fixed-dose combination of fluticasone furoate/vilanterol and a 52-week long-term trial of TRELEGY ELLIPTA 100/62.5/25 mcg compared with the fixed-dose combinations of fluticasone furoate/vilanterol . The exceptions are Arnuity Ellipta, Asmanex, and Trelegy Ellipa, which last for 24. Serious side effects from Trelegy Ellipta arent common, but they can occur. If you have concerns about gaining weight while taking Trelegy Ellipta, talk with your doctor. Some drugs can prolong (lengthen) a part of your heart rhythm called the QT interval. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. N Engl J Med. If you need financial support to pay for Trelegy Ellipta, help is available. To prevent yeast infection in your mouth, rinse with water (but do not swallow) after using Trelegy Ellipta. TRELEGY ELLIPTA is ready to use straight away. Trelegy Ellipta may not be right for you if you have certain medical conditions or other factors affecting your health. Read and follow all patient instructions provided with the inhaler device. The current stance of the Food and Drug Administration (FDA) is to avoid using expired medications. Chronic bronchitis is a. Cmax was reached about 30 minutes to 1 hour post-dose. COPD is a long-term lung disease that includes chronic bronchitis, emphysema, or both. Do not use Trelegy Ellipta if you have a severe allergy to milk proteins (like lactose). Asthma is a lung condition that makes it hard to breathe due to swelling and narrowing in your airways. The Trelegy Ellipta patient assistance program can provide your medication for free. The drug isnt meant to be used for sudden breathing problems caused by COPD. No preparation or checks of the inhaler are required. Step 1: Prepare a dose Wait to open the cover until you are ready to take your dose. * This strength of Trelegy Ellipta is abbreviated as 100/62.5/25 mcg. Trelegy Ellipta and Breo Ellipta both come as disposable inhalers. The insurance company will review the information and let you and your doctor know if your plan will cover Trelegy Ellipta. It is a maintenance medicine for long-term use to help prevent flare-ups. It contains these three active drugs that help relieve breathing symptoms of COPD and asthma: Trelegy Ellipta comes as an inhaler. There is insufficient data on the use of Trelegy Ellipta during pregnancy. In clinical trials, 4% to 9%* of people who took Trelegy Ellipta developed headaches. Trelegy Ellipta is a medicine used to relieve the symptoms of moderate to severe chronic obstructive pulmonary disease (COPD). "Trelegy" is the name of the medication inside the inhaler. For more information about what these drugs do, see the How Trelegy Ellipta works section below. Your doctor knows your medical condition the best and can give you a timeline of your treatment response. And some of these side effects can become serious, such as overheating or hallucinating. As with all medications, the cost of Trelegy Ellipta can vary. The actual price youll pay for either drug depends on your insurance plan, your location, and the pharmacy you use. If you do not have a fast-acting inhaler, call your doctor for a prescription. Umeclidinium is minimally orally absorbed. These lists contain examples of mild side effects that can occur with Trelegy Ellipta, with Symbicort, or with both drugs (when taken individually). Trelegy Ellipta is a once-daily therapy that combines three medicines into one inhaler. Trelegy Ellipta is approved in two different strengths for asthma, both given once daily. Note: This list is not all-inclusive and includes only common medications that may interact with Trelegy Ellipta. Chronic Obstructive Pulmonary Disease (COPD): TRELEGY ELLIPTA 100 mcg/62.5 mcg/25 mcg is used in adults for the long-term treatment of a lung disease called Chronic Obstructive Pulmonary Disease or COPD. Heres some information about the forms of each drug and how you take them. Trelegy Ellipta is also contraindicated in people with allergies to any of the ingredients in the medication, including fluticasone furoate, umeclidinium, vilanterol, lactose monohydrate, and magnesium stearate. In COPD patients: Upper respiratory tract infection, a runny nose and sore throat, pneumonia, taste disturbances, bronchitis, constipation, thrush (yeast infection) in your mouth and throat, painful and frequent urination (signs of a urinary tract infection), headache, nausea, vomiting, and diarrhea, back pain, mouth and throat pain, joint pain, cough, flu, hoarseness, and inflammation of the sinuses. Trelegy Ellipta (generic name: fluticasone furoate / umeclidinium / vilanterol) is an inhaler for asthma or COPD and must be used daily to be effective. Instead, youll use a rescue inhaler for sudden trouble breathing. Primary treatment of status asthmaticus or other acute episodes of COPD or asthma where intensive measures are required. Trelegy Ellipta can cause mild or serious side effects. Trelegy Ellipta is an option for the treatment of asthma in patients not controlled on inhaled corticosteroids and long-acting beta agonists alone. Symbicort has two active drug ingredients in it: budesonide and formoterol. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Seek emergency medical treatment or call 911 if your breathing problems get worse quickly. The experts say that at least 16 million Americans suffer with this challenging breathing problem. Research Triangle Park, NC: GlaxoSmithKline. There were no overdoses reported in people who took Trelegy Ellipta in clinical studies. Trelegy Ellipta was studied in over 10,000 patients with symptomatic chronic obstructive pulmonary disease (COPD) and a history of prior exacerbations (flare-ups). It is used for long-term maintenance treatment of these conditions. For both Trelegy Ellipta and Breo Ellipta, youll take one inhalation (puff) of the medication once a day. The following information describes dosages that are commonly used or recommended. Trelegy Ellipta can be taken once a day as it is a long-acting medicine that contains three medicines in one inhaler. Its effects are seen through the inhibition of M3 receptors, which leads to bronchodilation. Its FDA-approved for the long-term maintenance treatment of: However, Trelegy Ellipta isnt approved for use as a rescue inhaler to ease sudden breathing problems caused by either COPD or asthma. If youre breastfeeding, talk with your doctor before taking Trelegy Ellipta. If youre taking a beta-blocker, tell your doctor before you start using Trelegy Ellipta. Examples of non-potassium sparing diuretics include: If youre taking a non-potassium sparing diuretic, tell your doctor before you start using Trelegy Ellipta. For instance, some interactions can interfere with how well a drug works. If you drink alcohol, talk with your doctor whether its safe for you to continue drinking while youre taking Trelegy Ellipta. ICS medicines work by decreasing lung inflammation (swelling) that can cause breathing problems. Its the first FDA-approved medication containing three active drugs that can be used once a day for either COPD or asthma. We comply with the HONcode standard for trustworthy health information. They may be able to recommend a different medication that doesnt interact with Trelegy Ellipta. Breo (fluticasone furoate/vilanterol trifenatate), Zara Risoldi Cochrane, Pharm.D., M.S., FASCP, Combivent Respimat (ipratropium/albuterol), COPD lung vs. normal lungs in medical scans, vilanterol, which is a long-acting beta2-agonist (LABA), a bone that breaks more easily than it should, seeing halos or bright colors when looking at lights, swelling under your skin, typically in your eyelids, lips, hands, or feet, swelling of your tongue, mouth, or throat, one strip holds either 100 micrograms (mcg)* or 200 mcg** of fluticasone in each blister, the other strip holds 62.5 mcg of umeclidinium and 25 mcg of vilanterol in each blister, people who took Trelegy Ellipta had 15% fewer flare-ups each year than people who took fluticasone and vilanterol (two of the three drugs in Trelegy Ellipta), people who took Trelegy Ellipta had 25% fewer flare-ups each year than people who took umeclidinium and vilanterol (two of the three drugs in Trelegy Ellipta), 16% of people who took fluticasone and vilanterol, a long-acting beta2-agonist (LABA) and an, asthma symptoms arent well controlled on a long-term asthma medication such as an inhaled corticosteroid ICS), or, asthma is severe enough that it needs to be treated with both an ICS and a long-acting beta2-agonist (LABA) drug. There have been reports of serious allergic reactions, including anaphylaxis, when people with milk allergies take Trelegy Ellipta. Examples of examples of drugs that contain an anticholinergic medication include: If youre taking an anticholinergic drug, tell your doctor before you start using Trelegy Ellipta. However, you may not notice a change in your breathing symptoms right away. Because Trelegy Ellipta can also affect your heart rhythm, you shouldnt take these medications while using Trelegy Ellipta. With Trelegy Ellipta, there was a 97 mL improvement vs Breo and 54 mL improvement vs Anoro. What is TRELEGY ELLIPTA used for? Trelegy Ellipta also contains umeclidinium. Best food forward: Are algae the future of sustainable nutrition? How long does Trelegy stay in your system? Talk to your provider right away if you experience blurry vision, eye discomfort, or other changes in their vision after using Trelegy Ellipta. Learn more here. In asthma patients: common cold symptoms (13% to 15%), rhinitis (runny or stuffy nose), painful and frequent urination (signs of a urinary tract infection), upper respiratory tract infection (3% to 6%), bronchitis (3% to 5%), flu, respiratory tract infection, headache (5% to 9%), inflammation of the sinuses, and back pain. When an ICS and LABA are used together, there is not a significant increased risk in hospitalizations and death from asthma problems. mild allergic reaction *. sneezing. If you have sudden trouble breathing, your doctor will likely want you to use a rescue inhaler such as albuterol (Ventolin HFA, ProAir) or levalbuterol (Xopenex). Heres a comparison of how Trelegy Ellipta and Symbicort are alike and different. diarrhea. Therefore, these medications can cause some very similar side effects. Its available only as a brand-name medication. If you have questions about how to treat sudden breathing problems while taking Trelegy Ellipta, talk with your doctor. Once-Daily Single-Inhaler Triple versus Dual Therapy in Patients with COPD. Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare professional. Oral thrush is a possible side effect of taking an inhaled steroid medication. The drug was studied and shown to be safe and effective for long-term use in people with either COPD or asthma. Its not known if Trelegy Ellipta is safe to take during pregnancy. Three active drug ingredients make up Trelegy Ellipta: fluticasone furoate, umeclidinium, and vilanterol. Drink eight to 10 glasses of water or fluids every day to help prevent dehydration, which can make side effects worse. Strength. Trelegy Ellipta contains three different drugs (fluticasone, umeclidinium, and vilanterol), so you usually wont need to take another maintenance medication along with it. This is an inhaler that dispenses the drug as a spray, which you breathe into your lungs. This will help to keep you free of symptoms for about 24 hours. How quickly this medicine works for you will depend upon your previous treatments, your symptoms and lung function, and tolerance. Is it safe to use Trelegy Ellipta while pregnant or breastfeeding? With asthma, you may have symptoms such as: Its important to note that Trelegy Ellipta is meant to be used over time to control asthma symptoms. Vilanterol is also minimally absorbed orally. Accessed Oct. 21, 2020 at https://www.gsksource.com/pharma/content/dam/GlaxoSmithKline/US/en/Prescribing_Information/Trelegy/pdf/TRELEGY-ELLIPTA-PI-PIL-IFU.PDF, FDA Approves Trelegy Ellipta (fluticasone furoate/umeclidinium/vilanterol) for the Treatment of Asthma. Trelegy Ellipta has a half-life of between 11 and 24 hours, so it will stay in your bloodstream for up to 5 days after your last dose. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. Call your doctor right away if you have serious side effects. This can cause wheezing and fatigue (lack of energy). These lists contain examples of mild side effects that can occur with Trelegy Ellipta, with Breo Ellipta, or with both drugs (when taken individually). Its not known if Trelegy Ellipta is safe to use during pregnancy. However, its possible for the long-term use of inhaled steroids to cause weight gain. You should try to take your dose of Trelegy Ellipta at the same time each day. Trelegy is the name of the medication inside the inhaler. This is because both of these medications have a drug called an anticholinergic in them. They may be able to suggest a different treatment. Once the counter on the inhaler reads 0 (meaning that no doses are remaining), you can dispose of Trelegy Ellipta. (To learn more, see the Trelegy Ellipta side effects section above.). Keep all medicines out of the reach of children and pets. Accessed Oct. 4, 2022 at, Trelegy Ellipta [Prescribing Information]. Cardiovascular health: Insomnia linked to greater risk of heart attack. Can you just stop taking Trulicity? The medication is in a powder form, and youll inhale it into your lungs as you take one deep breath. In 2018, this use was expanded to include the daily maintenance treatment of airflow obstruction in patients with COPD. For more information on the possible side effects of Trelegy Ellipta, talk with your doctor or pharmacist. ** This strength of Trelegy Ellipta is abbreviated as 200/62.5/25 mcg. Below are examples of these side effects. A long-term study of Trelegy Ellipta looked at side effects of the medication over the course of 52 weeks. However, you should still check with your doctor or pharmacist before using any of these products while taking Trelegy Ellipta. You can find an updated list of ingredients at the end of the manufacturers patient information. In 2017, the Food and Drug Administration (FDA) approved Trelegy Ellipta to treat COPD. Rates of pneumonia were higher in the Trelegy Ellipta group. (For more about anticholinergics, see Trelegy Ellipta and other anticholinergic medications right below.). They may suggest a medication other than a beta-blocker. However, beta-blockers can block the effects of Trelegy Ellipta and cause the medication to not work properly. Rates of pneumonia were higher in patients receiving Trelegy triple therapy (8%) compared to Anoro (5%) or Breo (7%) in a 52-week study. Antimicrobial drugs are medications that are used to treat infections. Improvements in lung function have also been seen when Trelegy was compared to Symbicort Turbuhaler in 24-week studies or with Symbicort plus Spiriva in 12 week studies. Trelegy led to a superior and significant lung function (FEV1) improvement when compared to Breo and Anoro over one year. The FDA-approved strength for treatment of both COPD and asthma in adults is fluticasone furoate 100 mcg / umeclidinium 62.5 mcg / vilanterol 25mcg. How do I store Trelegy Ellipta? If you miss a dose of Trelegy Ellipta, take it as soon as you remember. Trelegy was also shown to reduce the annual rate of hospitalizations due to severe flare-ups (34% reduction vs. Anoro and 13% reduction vs. Breo). The inhaler isnt reusable, and you cant refill it. There are currently no generic forms of either drug. Before taking Trelegy Ellipta, talk with your doctor about your health history. If you miss a dose of Trelegy Ellipta, take it as soon as you remember, and then take your next dose at your usual time. You may. Do NOT take two doses at the same time. Accessed Oct, 22, 2020 at https://www.drugs.com/newdrugs/fda-approves-trelegy-ellipta-fluticasone-furoate-umeclidinium-vilanterol-asthma-5350.html. MNT is the registered trade mark of Healthline Media. Your monthly Trelegy Ellipta cost savings if eligible. constipation. Fluticasone is an inhaled steroid medication. It depends on what types of eye problems you have. Note: The Food and Drug Administration (FDA) tracks side effects of drugs they have approved. Its not known to interact with supplements or foods. For patients who do not respond adequately to TRELEGY ELLIPTA 100/62.5/25 mcg once daily, increasing the dose to TRELEGY ELLIPTA 200/62.5/25 mcg once daily may provide additional improvement in asthma control. Before taking Trelegy Ellipta, talk with your doctor and pharmacist. It is used once daily to help breathing symptoms and reduce the number of asthma or COPD flare-ups over the long-term. Instead, youll use a rescue inhaler for sudden trouble breathing. A one-year long clinical study with over 10,000 patients showed that Trelegy was more effective for reducing moderate-to-severe flare-ups (exacerbations) and improving lung function compared to using Breo 100 (an ICS/LABA) or Anora (a LAMA/LABA). So if youre taking Spiriva, youll need to stop using it before you start Trelegy Ellipta treatment. Its important to note that Trelegy Ellipta contains a powder form of lactose (a sugar in milk). Together, these drugs work in the body to decrease inflammation and increase the space in the airways to allow more air into the lungs. Call 911 if your symptoms feel life threatening or if you think youre having a medical emergency. It's a brand-name prescription drug used for COPD or asthma in. It is not known if this medicine is safe and effective in children younger than 18 years of age. Store the inhaler in the unopened tray until youre ready to use it. Stimulants including cocaine, meth, and ADHD medications are detectable for about 2 or 3 days. * This serious side effect is explained in more detail below in Side effect details.. These include: Note: For more information about the potential negative effects of Trelegy Ellipta, see the Trelegy Ellipta side effects section above. Studies also showed that treatment with Trelegy Ellipta decreased the risk of COPD exacerbations (flare-ups of COPD symptoms). Symbicort comes as a metered dose inhaler. If you no longer need to take Trelegy Ellipta and have leftover medication, its important to dispose of it safely. If youre interested in finding an alternative to Trelegy Ellipta, talk with your doctor. Symptoms of thrush include mouth pain or white patches in the mouth. If you are between the ages of 18 and 60, take no other medication or have no other medical conditions, side effects you are more likely to experience include: This is not a complete list of side effects, precautions or warnings, and others may occur. These inhalers are easy to use and include a dose counter so that you know when to refill your prescription. To help make sure that you dont miss a dose, try setting a reminder on your phone. This means that after 3-4 hours, there will only be approximately of the medication in your system as compared to the peak of the medication. These allergic reactions can be serious. Trelegy Ellipta shouldnt be used later in pregnancy (at or after 28 weeks) or during labor unless recommended by your doctor. (An active ingredient is the part of the medication that makes it work. So if you have a severe milk protein allergy, you may have an allergic reaction to this medication. Saliva tests can detect cannabis for approximately 24 hours after use. So its important that you keep taking Trelegy Ellipta every day even if you dont notice a difference in your breathing right away. The maximum recommended dosage is 1 inhalation of TRELEGY ELLIPTA 200/62.5/25 mcg once daily. Trelegy Ellipta has been evaluated in the treatment of asthma or COPD in studies ranging from 12- to 52-weeks long. Over one year, triple therapy with Trelegy was shown to improve rates of COPD flare-ups, improve lung function (FEV1), quality of life and rates of hospitalizations when compared to dual therapy such as Breo Ellipta (fluticasone and vilanterol) or Anoro Ellipta (umeclidinium and vilanterol). If you would like to report to the FDA a side effect youve had with Trelegy Ellipta, you can do so through MedWatch. Trelegy Ellipta is a combination medication. Drugs.com. If you have unused medication that has gone past the expiration date, talk with your pharmacist about whether you might still be able to use it. Higher FEV1s show better lung function, while lower FEV1s show poorer lung function. For more information about COPD and asthma, see the Trelegy Ellipta for COPD and Trelegy Ellipta for asthma sections above.