Do not take Hyzaar if pregnant or breastfeeding. Compare formulary status to other drugs in the same class. -Females of childbearing age should be informed of the consequences of exposure to this drug during pregnancy; ask these patients to report pregnancies as soon as possible. It consists of losartan (an angiotensin II receptor antagonist) and hydrochlorothiazide (a diuretic). [Package Insert]. Medscape Education. Controlled studies in pregnant women show no evidence of fetal risk. You take losartan once or twice per day. Losartan Potassium/Hydrochlorothiazide Dosage & Precautions Before taking this medication, tell your doctor or pharmacist if you are allergic to losartan or hydrochlorothiazide; or if you have any other allergies. commonly, these are "preferred" (on formulary) brand drugs. Dose adjustment is not usually necessary for the elderly. Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Other side effects include any of the following: cough, stomach pain, muscle cramps, back pain, headache and tiredness. Initial treatment: Hydrochlorothiazide 12.5 mg-Losartan 50 mg orally once a day; if blood pressure remains uncontrolled after 2 to 4 weeks, may initiate maximum dose. Sign up now . This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Losartan comes only as an oral tablet. The safety and efficacy of Losartan Potassium / Hydrochlorothiazide in children and adolescents under the age of 18 years have not been established. and formulary information changes. A 39-year-old member asked: what are the differences between losarta hctz (hydrochlorothiazide) and losartan potassium? The terminal elimination half lives of losartan and EXP3174 are about 1.5 to … Follow your doctor's orders or the directions on the label. This drug is not indicated for initial therapy except when hypertension is severe enough that the benefit of achieving prompt blood pressure control exceeds the risk of initiating combination therapy. Does bp meds cause you to loose weight? Manage and view all your plans together – even plans in different states. If dose titrated upward, not to exceed final titration of 100 mg/25 mg PO qDay or 50 mg/12.5 mg PO q12hr. Description and Brand Names; Before Using; Proper Use; Precautions; Side Effects; Products and services. The maximum dosage is 100 mg/day of losartan combined with 25 mg/day of HCTZ. [Package insert.] Fluconazole, an inhibitor of cytochrome P450 2C9, … HYPERTENSION: Hydrochlorothiazide 12.5 to 25 mg-Losartan 50 to 100 mg orally once a day Maximum dose: Hydrochlorothiazide 25 mg-Losartan 100 mg orally once a day Comments: -A patient whose blood pressure is not adequately controlled with hydrochlorothiazide or losartan monotherapy may be switched to hydrochlorothiazide 12.5 mg-losartan 50 mg orally once a day. These dosages have been shown to provide respective systemic exposures (AUCs) for losartan, its active metabolite and hydrochlorothiazide that are approximately 60, 60 and 30 times greater than those achieved in humans with 100 mg of losartan potassium in combination with 25 mg of hydrochlorothiazide. provider for the most current information. The dosage can be increased after 1 to 2 weeks of therapy to a maximum of one 320/25 tablet once daily as needed to control blood pressure [see Clinical Studies (14.2)].Maximum antihypertensive effects are attained within 2 to 4 weeks after a change in dose. MD. -Encourage patients to report any lightheadedness that may occur during treatment initiation and to stop taking this drug until consulting a physician if syncope occurs. Precautions. Usual Adult Dose of Losartan for Diabetic Nephropathy: Initial dose: 50 mg orally once a day. Max: 2 tab/day. Maximum dose: 100 mg orally once a day. … Hydrochlorothiazide and losartan side effects. Your doctor may increase your dose as needed. Find patient medical information for Losartan-Hydrochlorothiazide Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Drug information provided by: IBM Micromedex. Initiate a patient whose blood pressure is not … Adult dosage (ages 18 to 64 years) The starting dose is 50 mg losartan/12.5 mg hydrochlorothiazide or 100 mg losartan/12.5 mg hydrochlorothiazide, taken once per day. If you log out, you will be required to enter your username and password the next time you visit. -May increase dose if blood pressure remains uncontrolled after about 3 weeks. Losartan + Hydrochlorothiazide may cause drowsiness or dizziness. Hypertension. Usual Pediatric Dose … /viewarticle/942382 I have hypertension and have been prescribed Losartan HCTZ 50-12.5 MG my BP is 158 over 95 After reading about Losartan the 12.5 Mg's is not enough to give me lower BP, according to the PDR the average ... View answer. Check with your doctor immediately if any of the following side effects occur: Less common. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are dizzy or not alert. Losartan hctz dosage . The usual maintenance dose of Losartan potassium/Hydrochlorothiazide is one tablet of Losartan potassium/Hydrochlorothiazide 50 mg/12.5 mg (losartan 50 mg/HCTZ 12.5 mg) once daily. -Monitor serum electrolytes and renal function periodically. Based on the initial blood pressure response and/or losartan-hydrochlorothiazide side effects, the dosage may be increased or decreased. If affected, do not drive or take part in any activity in which you need to be alert. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Less than 2 years: 1 to 2 mg/kg/day (0.5 to 1 mg/pound) orally daily as a single dose or in 2 divided doses Maximum dose 37.5 mg per day 2 to 12 years: 1 to 2 mg/kg/day (0.5 to 1 mg/pound) orally daily as a single dose or in 2 divided doses Maximum dose 100 mg per day. List Losartan-Hydrochlorothiazide side effects by likelihood and severity. Check with your doctor immediately if any of the following side effects occur: Rare. The usual starting dose is Diovan HCT 160/12.5 mg once daily. If needed for blood pressure (BP) reduction, add hydrochlorothiazide (HCTZ) 12.5 mg PO once daily and/or increase the losartan dosage to 100 mg PO once daily. The more common side effects of taking Losartan include the following: ... HYZAAR- losartan potassium and hydrochlorothiazide tablet, film coated. Losartan hctz dosage. If further BP control is needed, increase the HCTZ dosage to 25 mg PO once daily. It is also used to reduce the risk of stroke in patients with high blood pressure and left ventricular hypertrophy. Premium Questions. 261435-overview If dose titrated upward, not to exceed final titration of 100 mg/25 mg PO qDay or 50 mg/12.5 mg PO q12hr, Decrease losartan to 25 mg PO qDay initially if volume depleted, Treat with losartan monotherapy; if reduction in blood pressure inadequate, initiate losartan /hydrochlorothiazide, Initial: 50 mg/12.5 mg PO qDay; may increase to 100 mg/12.5 mg PO qDay and subsequently to 100 mg/25 mg if necessary to control blood pressure, Discontinue as soon as possible when pregnancy is detected; affects renin-angiotensin system, causing oligohydramnios, which may result in fetal injury and/or death (see Pregnancy & Lactation), Hypersensitivity to losartan, hydrochlorothiazides, or sulfonamides, Coadministration with aliskiren in patients with diabetes, In patients with activated renin-angiotensin system, such as volume-or salt-depleted patients (eg, those being treated with high doses of diuretics), symptomatic hypotension may occur after initiation of treatment; correct volume or salt depletion prior to administration; do not use drug combination as initial therapy in patients with intravascular volume depletion, Stroke risk reduction may be less effective in African-Americans, Intravascular volume or salt depletion should be corrected prior to use, Monitor serum lithium levels in patients receiving lithium and hydrochlorothiazide, Inform female patients of childbearing age about consequences of exposure to losartan during pregnancy and importance of informing their physician about a pregnancy while on therapy; discontinue if pregnancy detected, Monitor for signs of fluid or electrolyte imbalance, including hyponatremia, hypomagnesemia, hypochloremic alkalosis, and hypokalemia, Hydrochlorothiazide may alter glucose tolerance and raise serum levels of cholesterol and triglycerides, If oliguria or hypotension occurs in neonate with history of in utero exposure, direct attention toward support of blood pressure and renal perfusion; exchange transfusions or dialysis may be required as a means of reversing hypotension and/or substituting for disordered renal function, Acute transient myopia and acute angle-closure glaucoma have been reported, particularly with history of sulfonamide or penicillin allergy (hydrochlorothiazide is a sulfonamide), Coadministration with corticosteroids, ACTH, or glycyrrhizin (found in liquorice) may intensify electrolyte depletion, particularly hypokalemia, Monitor renal function and potassium in susceptible patients, Exacerbation of systemic lupus erythematosus reported, Dual blockade of the renin-angiotensin-aldosterone system (ie, ARB plus an ACE inhibitor) in patients with established atherosclerotic disease, heart failure, or with diabetes with end organ damage is associated with a higher frequency of hypotension, syncope, hyperkalemia, and changes in renal function (including acute renal failure) as compared with use of a single renin-angiotensin-aldosterone system agent; closely monitor blood pressure, renal function and electrolytes in patients on losartan and other agents that affect the renin-angiotensin system (RAS), Hyperuricemia may occur or frank gout may be precipitated in patients receiving thiazide therapy; because losartan decreases uric acid, losartan in combination with hydrochlorothiazide attenuates diuretic-induced hyperuricemia, Hydrochlorothiazide decreases urinary calcium excretion and may cause elevations of serum calcium; monitor calcium levels, Concomitant use of other drugs that may increase serum potassium may lead to hyperkalemia, Photosensitivity reported; instruct patients to protect skin from sun and undergo regular skin cancer screening, Therapy can cause fetal harm when administered to a pregnant woman; use of drugs that act on renin-angiotensin system during second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death, Most epidemiologic studies examining fetal abnormalities after exposure to antihypertensive use in first trimester have not distinguished drugs affecting renin-angiotensin system from other antihypertensive agents; when pregnancy is detected, discontinue therapy as soon as possible, Hypertension in pregnancy increases maternal risk for pre-eclampsia, gestational diabetes, premature delivery, and delivery complications (eg, need for cesarean section, post-partum hemorrhage), Hypertension increases fetal risk for intrauterine growth restriction and intrauterine death; pregnant women with hypertension should be carefully monitored and managed accordingly, Not known whether losartan is excreted in human milk, but significant levels of losartan and its active metabolite were shown to be present in rat milk; thiazides appear in human milk; because of potential for adverse effects on nursing infant, a decision should be made whether to discontinue nursing or discontinue drug, taking into account importance of drug to mother. If experienced, these tend to have a Severe expression . Usual Adult Dose for Hypertension Initial dose: 1 tablet (12.5 mg-160 mg) orally once a day Maintenance dose: Titrate as necessary (every 1 to 2 weeks) up to a … I have hypertension and have been prescribed Losartan HCTZ 50-12.5 MG my BP is 158 over 95 After reading about Losartan the 12.5 Mg's is not enough to give me lower BP, according to the PDR the average ... View answer. informational and educational purposes only. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. 2002 What other drugs will affect losartan? Calculators including medical equations, dose/unit converters, and decision-tree analysis tools Pill identification tools Alternative medicines are a part of our premium offering. Blood pressures were recorded using ABPM immediately before randomization and after 8 weeks of active treatment. Morning SBP was reduced by 20.2 and 18.1 mmHg with combination therapy and by 7.1 and 9.1 mmHg with high-dose therapy in the Very-Elderly and Young/Elderly patients, respectively. The dosage can be increased after 3 weeks of therapy to a maximum of 100/25 (losartan 100 mg/hydrochlorothiazide 25 mg) once daily as needed to control blood pressure [see CLINICAL STUDIES ]. Drug information provided by: IBM Micromedex. Our general interest e-newsletter keeps you up to date on a wide variety of health topics. Detailed Losartan dosage information for adults and children. Common Questions and Answers about Losartan hctz dosage. The dosage can be increased after 3 weeks of therapy to a maximum of 100 mg/25 mg (losartan 100 mg/hydrochlorothiazide 25 mg) once daily as needed to control blood pressure [see CLINICAL STUDIES (14.2)]. Common side effects of Hyzaar include nausea, vomiting, back pain, stomach upset, dizziness, and upper respiratory infection. During the last six hours of the dosing interval, telmisartan 40 mg/HCTZ 12.5 mg and telmisartan 80 mg/HCTZ 12.5 mg reduced mean ambulatory diastolic blood pressure (DBP) to a greater extent than losartan 50 mg/HCTZ 12.5 mg (treatment differences 1.8 … Losartan And Hydrochlorothiazide (Oral Route) Print. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. commonly, these are "non-preferred" brand drugs. prescription products. Dosage/Direction for Use . For patients who do not respond adequately to Losartan potassium/Hydrochlorothiazide 50 mg/12.5 mg, the dosage may be increased to one tablet of Losartan potassium/Hydrochlorothiazide 100 mg/25 mg (losartan 100 mg/ HCTZ 25 mg) once daily. Find Lowest Prices. This FDA-approved indication is based on the findings of the LIFE trial which compared losartan vs. atenolol in patients with hypertension and LVH. Helmer A, Slater N, Smithgall S. … The above information is provided for general The usual starting dose of losartan potassium and hydrochlorothiazide tablet is 50/12.5 (losartan 50 mg/hydrochlorothiazide 12.5 mg) once daily. However, the dose is usually not more than 100 mg of losartan and 25 mg of hydrochlorothiazide per day. Merck & Co., Inc. The dose of this medicine will be different for different patients. Your list will be saved and can be edited at any time. Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature. The dose should generally be titrated at weekly intervals (i.e. Updated October 2018. The dosage can be increased after 3 weeks of therapy to a maximum of 100/25 (losartan 100 mg/hydrochlorothiazide 25 mg) once daily as needed to control blood pressure [see Clinical Studies (14.2) ]. This FDA-approved indication is based on the findings of the LIFE trial which compared losartan vs. atenolol in patients with hypertension and LVH. Does Moderate Drinking Increase Blood Pressure in Type 2 Diabetics? Losartan/HCTZ is contraindicated in patients with severe hepatic impairment (see section 4.3.). Suggest dosage for Losartan HCTZ . The recipient will receive more details and instructions to access this offer. Severe Interactions. Losartan is excreted in the urine, and in the feces via bile, as unchanged drug and metabolites. Primary efficacy end points were morning systolic BP (SBP) level and target BP achievement rate after 3 months of treatment. Diseases & Conditions, 2002 It is taken by mouth. To view formulary information first create a list of plans. It is used to treat high blood pressure. Applies to the following strengths: 12.5 mg-50 mg; 12.5 mg-100 mg; 25 mg-100 mg. Description and Brand Names; Before Using; Proper Use; Precautions; Side Effects; Products and services. Side Effects. The usual starting dose of HYZAAR is 50/12.5 (losartan 50 mg/hydrochlorothiazide 12.5 mg) once daily. SEVERE HYPERTENSION: The usual starting dose is 50 mg once daily. These dosages have been shown to provide respective systemic exposures (AUCs) for losartan, its active metabolite and hydrochlorothiazide that are approximately 60, 60 and 30 times greater than those achieved in humans with 100 mg of losartan potassium in combination with 25 mg of hydrochlorothiazide. Adding plans allows you to compare formulary status to other drugs in the same class. Initial: 50 mg/12.5 mg PO qDay. All material on this website is protected by copyright, Copyright © 1994-2021 by WebMD LLC. Talk to your pharmacist for more details. does this combination interfere with each other. Safety and efficacy have not been established in patients younger than 18 years. Last updated on Dec 6, 2019. commonly, these are generic drugs. 2)The starting daily dose for losartan is 25mg which can be increased gradually upto 100mg per day. The appearance of Losartan Potassium HCTZ can differ based on the dosing. Losartan And Hydrochlorothiazide (Oral Route) Print. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. The usual starting dose of losartan potassium and hydrochlorothiazide tablets is 50 mg/12.5 mg (losartan 50 mg/hydrochlorothiazide 12.5 mg) once daily. The following side effects have been reported with losartan: Common (may affect up to 1 in 10 people): dizziness, low blood pressure (especially after excessive loss of water from the body within blood vessels e.g. Add-on therapy: Hydrochlorothiazide 12.5 mg-Losartan 50 mg orally once a day; if blood pressure remains uncontrolled, initiate hydrochlorothiazide 12.5 mg-losartan 100 mg orally once a day, followed by hydrochlorothiazide 25 mg-losartan 100 mg orally once a day, if needed. Access your plan list on any device – mobile or desktop. Maximum dose: Hydrochlorothiazide 25 mg-Losartan 100 mg orally once a day Pregnancy, lactation; intravascular volume depletion. Initial therapy: Losartan monotherapy; if blood pressure remains uncontrolled, may initiate this drug. -May increase dose if blood pressure rem… Sign up now. It is a single product containing 2 medications: losartan and hydrochlorothiazide. For patients who do not respond adequately to Losartan potassium/Hydrochlorothiazide 50 mg/12.5 mg, the dosage may be increased to one tablet of Losartan potassium/Hydrochlorothiazide 100 mg/25 mg (losartan 100 mg/ HCTZ 25 mg) once daily. Maximum dose: Hydrochlorothiazide 25 mg-Losartan 100 mg orally once a day At these dosages, respective exposures (AUCs) of losartan, its active metabolite, and hydrochlorothiazide in rabbits were approximately 5, 1.5, and 1.0 times those achieved in humans with 100 mg losartan in combination with 25 mg hydrochlorothiazide. Losartan may be administered with other antihypertensive agents, especially with diuretics (e.g.hydrochlorothiazide) (see sections 4.3, 4.4, 4.5 and 5.1). Most Initial dose: 50 mg orally once a day. Common side effects include dizziness, back pain, and upper respiratory tract infections. Losartan dosing information. For oral dosage form (tablets): For high blood pressure: Adults—At first, one tablet once a day. I will try to address each of your question point wise. Drug information provided by: IBM Micromedex. Use: To reduce the risk of stroke in patients with hypertension and left ventricular hypertrophy, but there is evidence that this benefit does not apply to Black patients. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9yZWZlcmVuY2UubWVkc2NhcGUuY29tL2RydWcvaHl6YWFyLWxvc2FydGFuLWh5ZHJvY2hsb3JvdGhpYXppZGUtMzQyMzQw, View explanations for tiers and Use: Treatment of hypertension. HYPERTENSION WITH LEFT VENTRICULAR HYPERTROPHY: Free E-newsletter Subscribe to Housecall. Replacement therapy: Combination may be substituted for the individually titrated components, CrCl ≤30 mL/min: Do not use thiazide-containing products; loop diuretic preferred, CrCl >30 mL/min: No dosage adjustment required, Cough, incidence higher in previous cough related to ACE therapy (3-11%), Use of drugs that act on the renin-angiotensin system in second and third trimesters of pregnancy can result in oligohydramnios, reduced fetal renal function leading to anuria and renal failure, fetal lung hypoplasia, skeletal deformations, including skull hypoplasia, hypotension, and death, In the unusual case that there is no appropriate alternative to therapy with drugs affecting the renin- angiotensin system for a particular patient, apprise the mother of the potential risk to the fetus, Perform serial ultrasound examinations to assess the intra-amniotic environment; if oligohydramnios is observed, discontinue therapy, unless it is considered lifesaving for the mother, Fetal testing may be appropriate, based on week of gestation, Patients and physicians should be aware, however, that oligohydramnios may not appear until after fetus has sustained irreversible injury; closely observe neonates with histories of, In neonates with a history of in utero exposure to drug combination, if oliguria or hypotension occurs, support blood pressure and renal perfusion, Exchange transfusions or dialysis may be required as a means of reversing hypotension and replacing renal function, Thiazides can cross placenta, and concentrations reached in umbilical vein approach those in maternal plasma, Like other diuretics, the drug can cause placental hypoperfusion; it accumulates in amniotic fluid, with reported concentrations up to 19 times higher than in umbilical vein plasma, Use of thiazides during pregnancy is associated with a risk of fetal or neonatal jaundice or thrombocytopenia, Since they do not alter the course of preeclampsia, these drugs should not be used to treat hypertension in pregnant women, The use of hydrochlorothiazide for other indications in pregnancy should be avoided. Contact the applicable plan This medicine may also reduce the risk of stroke in certain patients. or Sign in. In female rats, however, the coadministration of doses as low as 10 mg/kg/day of losartan … Up to 2 tab once daily 2-4 wk later if needed. Paediatric population . Individual plans may vary The maximum dose is one tablet of Losartan potassium/Hydrochlorothiazide … 1928048-overview Along with its needed effects, a medicine may cause some unwanted effects. Merck Sharp & Dohme Corp.