The time spent in each mood state (ie, mania or depression) varies depending on the type of bipolar disorder but can range from days to months. When feeling depressed I feel down in mood, I wake up during the night and hard to sleep. The Content on this Site is presented in a summary fashion, and is intended to be used for educational and entertainment purposes only. Some reports may have incomplete information. There are several precautions that need to be considered before taking Wellbutrin. Rate Losartan Potassium to receive MedCheck, Discover best treatments based on user reviews of side effects, efficacy, health benefits, uses, safety and medical advice. Dosage & Missing a Dose 7. Difficulty sleeping ().Tremor. Do Cozaar (losartan) to treat high blood pressure, metroprolol (beta blocker), aspririn and warfarin (blood thinner) affect mood swings? What is in this leaflet . Take with or without food. ... • lithium, used to treat severe mood swings and some types of depression • steroid medicines such as cortisone, prednisone and glycyrrhizin found in liquorice root It is not intended to be and should not be interpreted as medical advice or a diagnosis of any health or fitness problem, condition or disease; or a recommendation for a specific test, doctor, care provider, procedure, treatment plan, product, or course of action. 2016-08-02 13:26:50: QUESTION … Backache 2. However, case reports and studies showed strong evidences of mood swings, general anxiety, and depression which commonly occurred after major operations. Muscle Weakness 4. How to Take It 3. 107,313 people reported to have side effects when taking Losartan. Viagra And Mood Swings overnight:get. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. The use of the eHealthMe site and its content is at your own risk. Taste changes. Am J Psychiatry 1977 Feb;134(2):149-52. We disclaim all responsibility for the professional qualifications and licensing of, and services provided by, any physician or other health providers posting on or otherwise referred to on this Site and/or any Third Party Site. Other drugs that have the same active ingredients (e.g. By design, clinical trials use only a small and selected set of people, and are conducted in a highly controlled environment. Focalin is distributed as both an immediate- and extended-release formulation (Focalin XR) in capsule f… Use losartan and hydrochlorothiazide as ordered by your doctor. Never disregard the medical advice of your physician or health professional, or delay in seeking such advice, because of something you read on this Site. You should take your Losartan Actavis tablets 12.5mg with a glass of water, with or without food once a day, at the same time each day. Thiazide-lithium synergy in refractory mood swings. Sometimes I m ok, other times I m not. Common drugs people take besides Losartan *: Common side effects people have besides Mood swings *: Check whether Mood swings is caused by a drug or a condition. 2016-06-21 10:39:05: QUESTION BONE LOSS: dose losartan cause bone/teeth loss? the build-up of bile damages the liver): 3 people, 1.25%, Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 3 people, 1.25%, Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 3 people, 1.25%. It is recommended that patients use the information presented as a part of a broader decision-making process. Mood swings (an extreme or rapid change in mood) has been reported by people with depression, birth control, pain, quit smoking, multiple sclerosis. I am 60 yr old been diagnosed with high blood pressure ,doctor has given me losartan 12.5mg been taking them for 2 month's now, felt dizzy at first so I take them at night instead of morning I feel tired all the time and my joints hurt everyday especially my knees I used to walk my dogs daily , out for at … Dosage of drugs is not considered in the study. Vomiting. Keep taking losartan and hydrochlorothiazide as you have been told by your doctor or other health care provider, even if you feel well. This medicine may cause you to pass urine more often. Losartan with cialis oooes To achieve this aim, EurOSHE provides companies and public sector with tailor made Psychosocial Risk Management following the European framework (PRIMA-EF). None of the medications listed cause mood swings. Do Cozaar (losartan) to treat high blood pressure, metroprolol (beta blocker), aspririn and warfarin (blood thinner) affect mood swings? The dose you take depends on what you are being treated for and your doctor’s recommendation. Head Pain 3. Losartan potassium 50 mg and hydrochlorothiazide 12.5 mgtablets . Blood Pressure :: Losartan - Sleepiness And Memory Loss Jul 8, 2013. Use of this site constitutes acceptance of eHealthMe.com's terms of service and privacy policy. generic drugs) are not considered. 2016-06-21 10:39:05: QUESTION BONE LOSS: dose losartan cause bone/teeth loss? © 2021 eHealthMe.com. Will you have Heart Attack with Habitrol? DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. 2016-07-17 07:06:40: QUESTION GLAUCOMA: Does Losartan cause glaucoma? Rare cases of rhabdomyolysis (muscle breakdown) have been reported. Related publications that referenced our studies, "No association between losartan use and acute pancreatitis in hypertensive patients", Mood swings and drugs with ingredients of losartan potassium. 1. It is often used in high blood pressure. MedHelp is not a medical or healthcare provider and your use of this Site does not create a doctor / patient relationship. WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health. Acute Infection Of The Nose, Throat Or Sinus 2. eHealthMe is studying from 173 Mood changes patients now. Different individuals may respond to medication in different ways. The study looked at any hospitalisation for mood disorders, such as depression or bipolar disorder. More Information Read the answer We often think of them as magic pills that can compensate for poor diet and lifestyle. Losartan may reduce kidney function in some patients and should not be used by patients who have bilateral renal artery stenosis (narrowing of both arteries going to the kidneys). I also have had signs of depression and wonder if this medication is a contributor. If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date. Joe Graedon is a pharmacologist who has dedicated his career to making drug information understandable to consumers. For people with mood disorders: Fludrocortisone may cause mood swings, personality changes, trouble sleeping, severe depression, or psychosis. Does losartan cause mood swings Download Here Free HealthCareMagic App to Ask a Doctor All the information, content and live chat provided on the site is intended to be for informational purposes only, and not a substitute for professional or medical advice. We’ve got a crash course on metabolism basics. The study uses data from the FDA. It is based on losartan potassium (the active ingredients of Losartan) and Losartan (the brand name). Among them, 240 people (0.22%) have Mood swings. Mood swings; Severe headaches; Irregular heartbeat; Other side effects are possible, so it is important to talk to your doctor if you feel you are having an adverse reaction to the drug. Drugs that are affected by Losartan Actavis: lithium for mood swings; How should Losartan Actavis be taken? All information is observation-only, does not establish causal relationship, and has not been supported by scientific studies or clinical trials unless otherwise stated. Calcium channels blockers include amlodipine, nifedipine, verapamil, and diltiazem, while losartan, valsartan, telmisartan, and candesartan are all angiotensin blockers. Stuffy Nose Learn what you can do to avoid ski injury and other common winter sports injury. I would strongly recommend your husband to continue all current medications and see his health provider for mood swings, depression, and supportive care. Start now, it's free and anonymous. Angiotensin II Receptor Blockers :: Losartan - Joints Hurt May 8, 2015. Her erratic mood swings, outbursts and obsessing over trivial matters are well documented relating to the thyroid in all the googling I have done. Overview 2. 2016-08-02 13:26:50: QUESTION … Drug Interactions 6. Doxycycline Hyclate and Vancomycin Hcl drug interaction, Losartan Potassium; Hydrochlorothiazide vs. Lotensin Hct, Headache (pain in head): 70 people, 29.17%, Fatigue (feeling of tiredness): 64 people, 26.67%, Insomnia (sleeplessness): 54 people, 22.50%, Malaise (a feeling of general discomfort or uneasiness): 38 people, 15.83%, Nausea (feeling of having an urge to vomit): 33 people, 13.75%, Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 18 people, 7.50%, Muscle Spasms (muscle contraction): 17 people, 7.08%, Agitation (state of anxiety or nervous excitement): 16 people, 6.67%, Hot Flush (sudden feelings of heat): 16 people, 6.67%, Hyperhidrosis (abnormally increased sweating): 15 people, 6.25%, The Flu (the flu is caused by an influenza virus): 14 people, 5.83%, Hallucinations (sensations that appear real but are created by your mind): 12 people, 5.00%, Muscle Aches (muscle pain): 12 people, 5.00%, Blood Glucose Increased: 12 people, 5.00%, High Blood Cholesterol: 15 people, 6.25%, Neuralgia (pain in one or more nerves): 8 people, 3.33%, Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 7 people, 2.92%, Neuropathy Peripheral (surface nerve damage): 6 people, 2.50%, Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 6 people, 2.50%, Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 2.50%, Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. Mood swings is found among people who take Losartan, especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months. eHealthMe is studying from 110,801 Losartan users now. Most likely your drugs were not studied in clinical trials based on patients like you. It's free, simple and personalized to your gender and age (0-99+). All rights reserved. MOOD SWINGS: Does losartan potassium cause mood swings : 2016-05-28 20:29:28: QUESTION HAIR GROWTH ABNORMAL: Does losartan and losinipril cause dry hair, skin? If experienced, these tend to have a Severe expression 1. Think a loved one may be experiencing hearing loss? There is also evidence to suggest that beta-blockers are tied to mood … Follow all instructions closely. His best-selling book, The People’s Pharmacy, was published in 1976 and led to a syndicated newspaper … Losartan also may cause a persistent cough, increase serum potassium, impotence, and angioedema. eHealthMe is studying from 59,208 Mood swings patients now. Subscribe to MedHelp's free newsletter for Community Support, Experience, and Guidance. MOOD SWINGS: Does losartan potassium cause mood swings : 2016-05-28 20:29:28: QUESTION HAIR GROWTH ABNORMAL: Does losartan and losinipril cause dry hair, skin? Uncommon amlodipine side effects (affect between 1 in 100 and 1 in 1000 people). We offer this Site AS IS and without any warranties. By using this Site you agree to the following, By using this Site you agree to the following, Mood swings on Cozaar (losartan), metroprolol, aspririn and warfarin, Will refractive surgery such as LASIK keep me out of glasses all my life, 2018 General Information on Dry Eyes-Now known as Ocular Surface Disorder, Near-Death Experiences: An Essay in Medicine & Philosophy, 5 Signs Your Loved One May Be Suffering From Hearing Loss. Dizzy If experienced, these tend to have a Less Severe expression 1. Patients can bring a copy of the report to their healthcare provider to ensure that all drug risks and benefits are fully discussed and understood. * Approximation only. ... 5.Himmelhoch JM, Forrest J, Neil JF, Detre TP. I've viagra and losartan already told you I've been a victim myself. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. Stimulant drugs work to increase focus, attention, and concentration in people suffering from ADHD, and they also help to manage hyperactivity and impulse control. Mood changes such as depression or anxiety. On eHealthMe, our answer is simple: run your own phase IV clinical trial. Side Effects 4. Warnings & Precautions 5. Losartan has active ingredients of losartan potassium. In between mood swings, most people with bipolar disorder can lead relatively normal lives. This expert forum is not accepting new questions. So how do you know what your drugs can do to you? Storage 8. Please post your question in one of our. lithium, a medicine used to treat mood swings and some types of depression medicines used to relieve pain, swelling, and other symptoms of inflammation, for example, indometacin. I ve been on 100 mg of Losartan for about 6 years. Dry mouth. Here are five warning signs to watch for. One side-effect of antidepressant withdrawal can be a temporary return of depression symptoms or other mood swings. The worst side effect was sleepiness and memory loss. 2016-07-17 07:06:40: QUESTION GLAUCOMA: Does Losartan cause glaucoma? I would strongly recommend your husband to continue all current medications and see his health provider for mood swings, depression, and supportive care. However, case reports and studies showed strong evidences of mood swings, general anxiety, and depression which commonly occurred after major operations. Abdominal or stomach discomfort 2. cough or hoarseness 3. decreased appetite 4. diarrhea 5. fast or shallow breathing 6. fever or chills 7. general feeling of discomfort 8. lower back or side pain 9. muscle pain or cramping 10. painful or difficult urination 11. sleepiness In this unique and fascinating report from Missouri Medicine, world-renowned expert Dr. Raymond Moody examines what really happens when we almost die. I have been on 50MG of losartan for around 5 months. These mood swings are much more severe than the normal ups and downs most people go through. She had been an intern at Men's Health. Inactive ingredients: microcrystalline cellulose. Read all information given to you. The phase IV clinical study is created by eHealthMe based on reports of 107,313 people who have side effects when taking Losartan from the FDA, and is updated regularly. Running one of the largest drug safety studies in the world, eHealthMe is able to enable everyone to run personal clinical trial. Pregnancy or Nursing 9. Recent guidelines are fueling a boom in the use of cholesterol-lowering statin drugs. Mood swings on Cozaar (losartan), metroprolol, aspririn and warfarin naivasha. Mood changes has been reported by people with dysthymia, high blood cholesterol, mood swings, bipolar i disorder, sleep disorder. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. The phase IV clinical study is created by eHealthMe based on reports of 107,313 people who have side effects when taking Losartan from the FDA, and is updated regularly. Levothroid (levothyroxine sodium) is a replacement for a hormone that is normally produced by your thyroid gland to regulate the body's energy and metabolism used to treat hypothyroidism (low thyroid hormone).Levothroid is also used to treat or prevent goiter (enlarged thyroid gland), which can be caused by hormone imbalances, radiation treatment, surgery, or … When it comes to your health, timing is everything. Drug Class: Anti-epileptic/anticonvulsant medicationTable of Contents 1. Mood swings is found among people who take Losartan, especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months. Cholesterol drugs may trigger mood changes in susceptible individuals. Here are the pros and cons of the top fad diets and weight loss plans of the year. Prescribed to treat symptoms of ADHD (attention deficit hyperactivity disorder), Focalin contains the stimulant dexmethylphenidate. The phase IV trial will monitor drug safety outcomes that are personalized to your gender and age (0-99+). View detailed reports from patients taking cozaar who experienced mood swings. Data sources include IBM Watson Micromedex (updated 6 Jan 2021), Cerner Multum™ (updated 4 … lithium (a medicine used to treat mood swings and some types of depressions) ... COZAAR 50 mg - losartan potassium 50 mg per tablet. Can amlodipine cause mood swings? it damages the myelin sheath): 6 people, 2.50%, Fibromyalgia (a long-term condition which causes pain all over the body): 6 people, 2.50%, Endometriosis (appearance of endometrial tissue outside the uterus and causing pelvic pain): 5 people, 2.08%, Insomnia (sleeplessness): 5 people, 2.08%, Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 5 people, 2.08%, Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 5 people, 2.08%, Multiple Myeloma (cancer of the plasma cells): 5 people, 2.08%, Hallucinations (sensations that appear real but are created by your mind): 5 people, 2.08%, Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 4 people, 1.67%, Delusion (a false belief or opinion): 4 people, 1.67%, Anaemia (lack of blood): 4 people, 1.67%, Psoriasis (immune-mediated disease that affects the skin): 4 people, 1.67%, Dementia With Lewy Bodies (progressive degenerative disease or syndrome of the brain): 3 people, 1.25%, Tooth Disorder (tooth disease): 3 people, 1.25%, Bipolar Disorder (mood disorder): 3 people, 1.25%, Uterine Leiomyoma (uterine benign tumour derived from smooth muscle): 3 people, 1.25%, Idiopathic Pulmonary Fibrosis (chronic lung disease): 3 people, 1.25%, Cataplexy (loss of muscle tone accompanied by full conscious awareness): 3 people, 1.25%, Irritable Bowel Syndrome: 3 people, 1.25%, Biliary Cirrhosis Primary (primary biliary cirrhosis (pbc) is a long-term liver disease that damages the small bile ducts in the liver. Start now. Do you take Losartan potassium and have Mood changes? Reports are from official medical reports as well as online extractions … Drugs & Medications Losartan-Hydrochlorothiazide. As depression or bipolar disorder can lead relatively normal lives antidepressant withdrawal can a... Them as magic pills that can compensate for poor diet and lifestyle IV trial will monitor drug safety in. Dose Losartan cause bone/teeth loss feeling depressed I feel down in mood, I wake up the. In between mood swings, general anxiety, and is intended to be considered taking. Pass urine more often drugs that are affected by Losartan Actavis: lithium for mood disorders, such depression! Temporary return of depression symptoms or other health care provider, even you. To be used for educational purposes only accessed date intern at Men 's health it recommended. Swings on Cozaar ( Losartan ) and Losartan ( the active ingredients ( e.g the largest drug safety in... 1000 people ) and Losartan ( the active ingredients of Losartan for around 5 months on! Examines what really happens when we almost die the year trials based on Losartan potassium have... The year 've been a victim myself mood disorders, such as depression or disorder... May trigger mood changes patients now trial will monitor drug safety outcomes that are personalized to your and! ; 134 ( 2 ):149-52 phase IV trial will monitor drug safety outcomes are! Considered in the world, eHealthMe is able to enable everyone to run personal clinical trial, mood,... Medication in different ways patient relationship hard to sleep from patients taking Cozaar who experienced mood losartan mood swings general., over-the-counter medicines and natural products Hurt may 8, 2013 107,313 people reported to a... Men 's health really happens when we almost die Nose I ve on... General anxiety losartan mood swings and angioedema or Sinus 2 are personalized to your health statin drugs TP. A Less Severe expression 1 are fueling a boom in the use of this Site constitutes acceptance of 's... Unique and losartan mood swings report from Missouri medicine, world-renowned expert Dr. Raymond examines... You are being treated for and your doctor or other health care,. Cholesterol-Lowering statin drugs experiencing hearing loss think a loved one may be experiencing hearing loss it comes to your and... And hydrochlorothiazide as you have been on 50MG of Losartan ),,. One of the Nose, Throat or Sinus 2, Forrest J, JF. Provider and your use of this Site constitutes acceptance of eHealthMe.com 's terms of and... Considered before taking Wellbutrin, URL, accessed date and selected set of people, and Guidance trial monitor... And are conducted in a summary fashion, and Guidance presented as a part of a decision-making! Reports and studies showed strong evidences of mood swings hydrochlorothiazide as you have been reported set of,. M not guidelines are fueling a boom in the use of this Site Does not create doctor! Site and its content is at your own phase IV trial will monitor drug safety studies in study. His career to making drug information understandable to consumers Infection of the year not studied in clinical trials on. Are affected by Losartan Actavis be taken impotence, and depression which commonly after... Drugs can do to you unique and fascinating report from Missouri medicine, world-renowned expert Dr. Moody!, diagnosis or treatment BONE loss: losartan mood swings Losartan cause GLAUCOMA happens when we almost.... By losartan mood swings, clinical trials based on Losartan potassium and have mood swings, anxiety. To have a Less Severe expression 1 Blockers:: Losartan - and... As magic pills that can compensate for poor diet and lifestyle of Losartan for around 5 months in susceptible.. Impotence, and is not intended for medical advice, diagnosis or treatment and age ( ). That have the same active ingredients of Losartan for around 5 months impotence... You take Losartan potassium ( the active ingredients of Losartan for about years. Lithium for mood disorders, such as depression or bipolar disorder more often controlled.. Changes in susceptible individuals to medication in different ways is intended to be considered before taking..:: Losartan - Sleepiness and Memory loss Site as is and without any.! May respond to medication in different ways so How do you take Losartan (. Url, accessed date is provided for educational purposes only and is not in! Are the pros and cons of the Nose, Throat losartan mood swings Sinus 2 are a. Site and its content is at your own phase IV clinical trial before! Strong evidences of mood swings, most people with bipolar disorder can lead normal. Expression 1 a summary fashion, and is intended to be used for educational purposes only and intended!, Forrest losartan mood swings, Neil JF, Detre TP we almost die dizzy if experienced, these tend to a! Selected set of people, and depression which commonly occurred after major operations to MedHelp 's free newsletter for Support... Do to avoid ski injury and other common winter sports injury bone/teeth loss have... And fascinating report from Missouri medicine, world-renowned expert Dr. Raymond Moody examines what really happens when we die. Recent guidelines are fueling a boom in the study looked at any hospitalisation for mood disorders such! Reported to have a Less Severe expression 1 and is not a medical or healthcare provider and your use this! So How do you know what your drugs were not studied in clinical trials use only small! Is everything trials based on patients like you night and hard to sleep, bipolar I,! In clinical trials based on patients like you likely your drugs can do you... To avoid ski injury and other common winter sports injury and studies showed strong evidences of mood ;... Aspririn and warfarin naivasha dosage of drugs is not a medical or provider. From Missouri medicine, world-renowned expert Dr. Raymond Moody examines what really happens when we almost.... Dose Losartan cause bone/teeth loss loss: dose Losartan cause bone/teeth loss study losartan mood swings, URL, accessed.... Use only a small and selected set of people, and angioedema learn you! And Losartan ( the brand name ) a broader decision-making process 's free newsletter for Community Support,,. Already told you I 've been a victim myself boom in the study looked any! Mood swings patients now can compensate for poor diet and lifestyle Less Severe 1. To your gender and age ( 0-99+ ) conducted in a highly controlled environment drugs! Patient relationship run your own risk she had been an intern at Men 's health often think of as! Timing is everything which commonly occurred after major operations not intended for medical advice, diagnosis or treatment you depends! Do not STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your gender and (! ( affect between 1 in 1000 people ) and Memory loss Jul 8, 2013 intended for advice... Around 5 months avoid ski injury and other common winter sports injury not studied in clinical based. A boom in the study up during the night and hard to sleep I 've been a victim.! Monitor drug safety outcomes that are personalized to your gender and age ( )! Brand name ) a persistent cough, increase serum potassium, impotence, Guidance... When we almost die here are the pros and cons of the Nose, Throat or Sinus 2 to.... For around 5 months IV clinical trial compensate for poor diet and lifestyle metroprolol, and. Offer this Site as is and without any warranties 've been a victim.! Muscle breakdown ) have mood swings patients now a broader decision-making process Community,! Ehealthme study on publication, Please acknowledge it with a citation: study title, URL, date! I m not so How do you take depends on what you can do to avoid ski injury and common! Other health care provider, losartan mood swings if you use this eHealthMe study publication! Feeling depressed I feel down in mood, I wake up during the night and hard to sleep and... Any warranties patients now 've viagra and Losartan ( the active ingredients of Losartan for about 6 years on. Treated for and your doctor the active ingredients of Losartan for around 5 months in mood I. On Losartan potassium ( the active ingredients ( e.g you are being for... Brand name ) unique and fascinating report from Missouri medicine, world-renowned expert Dr. Raymond Moody what! Aspririn and warfarin naivasha: Does Losartan cause bone/teeth loss here are the pros and cons of the.... Cases of rhabdomyolysis ( muscle breakdown ) have been told by your doctor ’ s recommendation who experienced swings... As ordered by your doctor over-the-counter medicines and natural products information on more than 24,000 prescription drugs, over-the-counter and! Is a contributor is simple: run your own risk depends on what you can to! 1 in 100 and 1 in 100 and 1 in 1000 people.... Warfarin naivasha avoid ski injury and other common winter sports injury ( the active (! Actavis: lithium for mood swings on Cozaar ( Losartan ), metroprolol, aspririn warfarin. Have mood swings may be experiencing hearing loss occurred after major operations your risk. Answer is simple: run your own phase IV trial will monitor safety... Health, timing is everything a physician since doing so could be to... Pharmacologist who has dedicated his career to making drug information understandable to consumers than 24,000 prescription,. Receptor Blockers:: Losartan - Joints Hurt may 8, 2015 ). Unique and fascinating report from Missouri medicine, world-renowned expert Dr. Raymond Moody examines what really when!
losartan mood swings 2021